STOCK Dbnltm1a(KOMP)Wtsi/CipheOrl

Status

Available to order

EMMA IDEM:09624
Citation informationRRID:IMSR_EM:09624 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameSTOCK Dbnltm1a(KOMP)Wtsi/CipheOrl
Alternative nameEPD0504_4_A04
Strain typeTargeted Mutant Strains
Allele/Transgene symbolDbnltm1a(KOMP)Wtsi
Gene/Transgene symbolDbnl
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Centre d'ImmunoPhenomique - Ciphe
Provider affiliationCentre d
Genetic informationThis mouse line originates from KOMP ES clone EPD0504_4_A04. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NCrl males

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased circulating glucose level / IMPC
  • decreased locomotor activity / IMPC
  • abnormal retina vasculature morphology / IMPC
  • decreased hematocrit / IMPC
  • abnormal auditory brainstem response / IMPC
  • abnormal retina inner nuclear layer morphology / IMPC
  • abnormal retina blood vessel morphology / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • persistence of hyaloid vascular system / IMPC
  • decreased circulating cholesterol level / IMPC
  • increased mean corpuscular volume / IMPC
  • increased heart weight / IMPC
  • decreased total retina thickness / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • decreased hemoglobin content / IMPC
  • abnormal optic disk morphology / IMPC
  • decreased erythrocyte cell number / IMPC
  • increased startle reflex / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased circulating serum albumin level / IMPC
  • decreased circulating alkaline phosphatase level / IMPC
  • increased fluid intake / IMPC
  • decreased circulating total protein level / IMPC
  • increased grip strength / IMPC
MGI phenotypes (gene matching)
  • ruffled hair / MGI
  • tremors / MGI
  • paresis / MGI
  • hindlimb paralysis / MGI
  • convulsive seizures / MGI
  • abnormal lung morphology / MGI
  • decreased body weight / MGI
  • impaired coordination / MGI
  • limb grasping / MGI
  • impaired swimming / MGI
  • abnormal cardiovascular system physiology / MGI
  • decreased IgM level / MGI
  • abnormal T cell activation / MGI
  • respiratory distress / MGI
  • emphysema / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • abnormal T cell physiology / MGI
  • decreased immunoglobulin level / MGI
  • abnormal synaptic vesicle recycling / MGI
  • increased spleen weight / MGI
  • decreased T cell proliferation / MGI
  • immune system phenotype / MGI
  • reproductive system phenotype / MGI
  • decreased IgG1 level / MGI
  • decreased interleukin-2 secretion / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • generalized edema / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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