B6(Cg)-Mecrtm1c(EUCOMM)Wtsi/WtsiCnbcOulu
| Status | Available to order |
| EMMA ID | EM:09678 |
| International strain name | B6(Cg)-Mecrtm1c(EUCOMM)Wtsi/WtsiCnbcOulu |
| Alternative name | C57Bl/6 Mecrtm1c |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Mecrtm1c(EUCOMM)Wtsi, |
| Gene/Transgene symbol | Mecr |
Information from provider
| Provider | Alexander J. Kastaniotis |
| Provider affiliation | Faculty of Biochemistry and Molecular Medicine, University of Oulu |
| Genetic information | Exon 2 of Mecr (mitochondrial enoyl CoA reductase) is floxed (loxP flanked). |
| Phenotypic information | Homozygous:The mice homozygous for loxP sites on exon 2 of Mecr are apparently normal.Heterozygous:The mice heterozygous for loxP sites are indistinguishable from wild type mice. |
| Breeding history | Heterozygous frozen embryos of B6Brd;B6N-Tyrc-Brd Mecrtm1a(EUCOMM)Wtsi/WtsiCnbc were purchased from EMMA (EM:04825). The pups born after embryo transfer were backcrossed with C57BL/6JOlaHsd. The heterozygous pups born from previous breeding were crossed with B6.Cg-Tg(CTFLPe)9205Dym/J (backcrossed to C57BL/6JOlaHsd) to delete FRT flanked selection cassette and crossbred to generate mice homozygous for loxP sites. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | homozygous 0 |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- MEPAN syndrome / Orphanet_508093
Literature references
- Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice.;Nair Remya R, Kerätär Juha M, Autio Kaija J, Masud Ali J, Finnilä Mikko A J, Autio-Harmainen Helena I, Miinalainen Ilkka J, Nieminen Pentti A, Hiltunen J Kalervo, Kastaniotis Alexander J, ;2017;Human molecular genetics;26;2104-2117; 28369354
- Impaired Mitochondrial Fatty Acid Synthesis Leads to Neurodegeneration in Mice.;Nair Remya R, Koivisto Henna, Jokivarsi Kimmo, Miinalainen Ilkka J, Autio Kaija J, Manninen Aki, Poutiainen Pekka, Tanila Heikki, Hiltunen J Kalervo, Kastaniotis Alexander J, ;2018;The Journal of neuroscience : the official journal of the Society for Neuroscience;38;9781-9800; 30266742