B6;CBACa-Tg(MMTV-VEGFB*)1Sjh/H

Status	Available to order
EMMA ID	EM:09695
Citation information	RRID:IMSR_EM:09695 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6;CBACa-Tg(MMTV-VEGFB*)1Sjh/H
Alternative name	C57BL/6J x CBA/Ca
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(MMTV-VEGFB*)1Sjh
Gene/Transgene symbol	Tg(MMTV-VEGFB*)1Sjh

Information from provider

Provider	David Bates
Provider affiliation	Cancer Biology, Division of Cancer and Stem cells, University of Nottingham
Genetic information	The genetic background of the embryos used for transgene injection is C57BL/6J x CBA/Ca.
Phenotypic information	Homozygous: Unknown. Heterozygous: Transgenic females are relatively infertile. They have poor milk production in order to wean pups, thus the transgenic line is maintained in males.
Breeding history	Sib-mated for >10 generations.
References	Mammary alveolar development during lactation is inhibited by the endogenous antiangiogenic growth factor isoform, VEGF165b.;Qiu Yan, Bevan Heather, Weeraperuma Sudath, Wratting Daniel, Murphy David, Neal Christopher R, Bates David O, Harper Steven J, ;2008;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;22;1104-12; 18032632 Ovarian VEGF(165)b expression regulates follicular development, corpus luteum function and fertility.;Qiu Y, Seager M, Osman A, Castle-Miller J, Bevan H, Tortonese D J, Murphy D, Harper S J, Fraser H M, Donaldson L F, Bates D O, ;2012;Reproduction (Cambridge, England);143;501-11; 22232745
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archiving	heterozygous C57BL/6 males
Breeding at archiving centre	Cross to C57BL/6

Literature references

Mammary alveolar development during lactation is inhibited by the endogenous antiangiogenic growth factor isoform, VEGF165b.;Qiu Yan, Bevan Heather, Weeraperuma Sudath, Wratting Daniel, Murphy David, Neal Christopher R, Bates David O, Harper Steven J, ;2008;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;22;1104-12; 18032632
Ovarian VEGF(165)b expression regulates follicular development, corpus luteum function and fertility.;Qiu Y, Seager M, Osman A, Castle-Miller J, Bevan H, Tortonese D J, Murphy D, Harper S J, Fraser H M, Donaldson L F, Bates D O, ;2012;Reproduction (Cambridge, England);143;501-11; 22232745

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