C57BL/6N-Loxl3tm1a(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:09699
Citation informationRRID:IMSR_EM:09699 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Loxl3tm1a(EUCOMM)Wtsi/H
Alternative nameEPD0336_7_H09
Strain typeTargeted Mutant Strains
Allele/Transgene symbolLoxl3tm1a(EUCOMM)Wtsi
Gene/Transgene symbolLoxl3
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0336_7_H09. For further details on the construction of this clone see the page at the IKMC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • short mandible / MGI
  • abnormal vomer bone morphology / MGI
  • cleft palate / MGI
  • abnormal vertebral body morphology / MGI
  • abnormal craniofacial morphology / MGI
  • abnormal pulmonary alveolus morphology / MGI
  • no phenotypic analysis / MGI
  • abnormal chest morphology / MGI
  • abnormal spine curvature / MGI
  • abnormal vertebral column morphology / MGI
  • abnormal vertebral body development / MGI
  • cardiovascular system phenotype / MGI
  • respiratory system phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal palate development / MGI
  • failure of palatal shelf elevation / MGI
  • palatal shelves fail to meet at midline / MGI
  • integument phenotype / MGI
  • postnatal lethality, complete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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