C57BL/6NTac-Tmem132atm1a(KOMP)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:09726
Citation informationRRID:IMSR_EM:09726 

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International strain nameC57BL/6NTac-Tmem132atm1a(KOMP)Wtsi/WtsiH
Alternative nameEPD0111_5_B06
Strain typeTargeted Mutant Strains
Allele/Transgene symbolTmem132atm1a(KOMP)Wtsi
Gene/Transgene symbolTmem132a
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0111_5_B06. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
  • abnormal tail morphology / IMPC
  • syndactyly / IMPC
  • abnormal limb bud morphology / IMPC
  • abnormal craniofacial morphology / IMPC
  • increased total body fat amount / IMPC
  • unresponsive to tactile stimuli / IMPC
  • decreased bone mineral content / IMPC
  • abnormal bone structure / IMPC
  • abnormal limb morphology / IMPC
  • abnormal facial morphology / IMPC
  • spina bifida / IMPC
  • abnormal embryo size / IMPC
  • abnormal head shape / IMPC
  • abnormal cranium morphology / IMPC
  • abnormal neural tube closure / IMPC

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

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Practical information

Genotyping protocol

Example health report
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Material Transfer Agreement (MTA)
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