C57BL/6N-Pla2g6tm1a(EUCOMM)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:09779
Citation informationRRID:IMSR_EM:09779 

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International strain nameC57BL/6N-Pla2g6tm1a(EUCOMM)Wtsi/WtsiH
Alternative namePla2g6-G04
Strain typeTargeted Mutant Strains
Allele/Transgene symbolPla2g6tm1a(EUCOMM)Wtsi
Gene/Transgene symbolPla2g6
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone Pla2g6-G04. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
  • kyphosis / MGI
  • tremors / MGI
  • hindlimb paralysis / MGI
  • abnormal spinal cord morphology / MGI
  • weight loss / MGI
  • ataxia / MGI
  • hyperactivity / MGI
  • impaired coordination / MGI
  • abnormal gait / MGI
  • increased exploration in new environment / MGI
  • abnormal motor coordination/balance / MGI
  • impaired limb coordination / MGI
  • reduced male fertility / MGI
  • male infertility / MGI
  • blindness / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • premature death / MGI
  • abnormal brain morphology / MGI
  • neurodegeneration / MGI
  • muscular atrophy / MGI
  • abnormal sciatic nerve morphology / MGI
  • asthenozoospermia / MGI
  • axonal dystrophy / MGI
  • abnormal locomotor coordination / MGI
  • abnormal nervous system morphology / MGI
  • abnormal myelin sheath morphology / MGI
  • increased cholesterol level / MGI
  • decreased double-positive T cell number / MGI
  • abnormal spinal cord ventral horn morphology / MGI
  • abnormal brainstem morphology / MGI
  • abnormal axon morphology / MGI
  • axon degeneration / MGI
  • abnormal mitochondrion morphology / MGI
  • abnormal brain white matter morphology / MGI
  • abnormal spinal cord grey matter morphology / MGI
  • abnormal synaptic bouton morphology / MGI
  • abnormal astrocyte physiology / MGI
  • skeletal muscle atrophy / MGI
  • axonal spheroids / MGI
  • decreased grip strength / MGI
  • abnormal apolipoprotein level / MGI
  • abnormal mitochondrial crista morphology / MGI
  • abnormal cell cytoskeleton morphology / MGI

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Practical information

Genotyping protocol

Example health report
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