C57BL/6N-Nr4a1^{tm1a(EUCOMM)Wtsi}/Biat

Status	Available to order
EMMA ID	EM:09780
Citation information	RRID:IMSR_EM:09780 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-Nr4a1^{tm1a(EUCOMM)Wtsi}/Biat
Alternative name	EPD0241_3_H01
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Nr4a1^{tm1a(EUCOMM)Wtsi}
Gene/Transgene symbol	Nr4a1
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Thierry Léveillard
Provider affiliation	Departement de Génétique, Université Pierre et Marie Curie - Inserm - CNRS
Genetic information	This mouse line originates from EUCOMM ES clone EPD0241_3_H01. For further details on the construction of this clone see the page at the IKMC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	University of Veterinary Medicine, Vienna, Austria

Disease and phenotype information

MGI phenotypes (gene matching)

abnormal vascular permeability / MGI
no abnormal phenotype detected / MGI
increased tumor growth/size / MGI
endocrine/exocrine gland phenotype / MGI
immune system phenotype / MGI
increased susceptibility to endotoxin shock / MGI
abnormal uterus physiology / MGI
decreased Ly6C low monocyte number / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Conditional ready allele (tm1c allele), service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.

INFRAFRONTIER^® and European Mouse Mutant Archive - EMMA^® are registered trademarks at the European Union Intellectual Property Office (EUIPO).

C57BL/6N-Nr4a1tm1a(EUCOMM)Wtsi/Biat