FVB-Tg(KRT14-Vegfd)1Ali/Oulu

Status	Available to order
EMMA ID	EM:09798
Citation information	RRID:IMSR_EM:09798 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	FVB-Tg(KRT14-Vegfd)1Ali/Oulu
Alternative name	K14-mVEGF-D
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(KRT14-Vegfd)1Ali
Gene/Transgene symbol	Tg(KRT14-Vegfd)1Ali

Information from provider

Provider	Kari Alitalo
Provider affiliation	Translational Cancer Biology Program, Wihuri Research Institute, University of Helsinki
Genetic information	Transgenic, murine Vegfd overexpression driven by keratin 14 promoter.
Phenotypic information	Homozygous: Homozygous were not analyzed. Heterozygous: Hyperplastic lymphatic vasculature in the skin (Haiko et al. Mol Cell Biol. 2008 Aug;28(15):4843-50); changes in tumor inflammation and experimental skin tumor growth (Honkanen et al., 2016)
References	Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos.;Haiko Paula, Makinen Taija, Keskitalo Salla, Taipale Jussi, Karkkainen Marika J, Baldwin Megan E, Stacker Steven A, Achen Marc G, Alitalo Kari, ;2008;Molecular and cellular biology;28;4843-50; 18519586 Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors.;Honkanen Hanne-Kaisa, Izzi Valerio, Petäistö Tiina, Holopainen Tanja, Harjunen Vanessa, Pihlajaniemi Taina, Alitalo Kari, Heljasvaara Ritva, ;2016;Neoplasia (New York, N.Y.);18;436-46; 27435926
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	University of Oulu, Oulu, Finland

Literature references

Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos.;Haiko Paula, Makinen Taija, Keskitalo Salla, Taipale Jussi, Karkkainen Marika J, Baldwin Megan E, Stacker Steven A, Achen Marc G, Alitalo Kari, ;2008;Molecular and cellular biology;28;4843-50; 18519586
Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors.;Honkanen Hanne-Kaisa, Izzi Valerio, Petäistö Tiina, Holopainen Tanja, Harjunen Vanessa, Pihlajaniemi Taina, Alitalo Kari, Heljasvaara Ritva, ;2016;Neoplasia (New York, N.Y.);18;436-46; 27435926

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

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Legally binding conditions for the transfer

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