FVB-Tg(KRT14-Vegfd)1Ali/Oulu
| Status | Available to order |
| EMMA ID | EM:09798 |
| International strain name | FVB-Tg(KRT14-Vegfd)1Ali/Oulu |
| Alternative name | K14-mVEGF-D |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(KRT14-Vegfd)1Ali, |
| Gene/Transgene symbol | Tg(KRT14-Vegfd)1Ali |
Information from provider
| Provider | Kari Alitalo |
| Provider affiliation | Translational Cancer Biology Program, Wihuri Research Institute, University of Helsinki |
| Genetic information | Transgenic, murine Vegfd overexpression driven by keratin 14 promoter. |
| Phenotypic information | Homozygous:Homozygous were not analyzed.Heterozygous:Hyperplastic lymphatic vasculature in the skin (Haiko et al. Mol Cell Biol. 2008 Aug;28(15):4843-50); changes in tumor inflammation and experimental skin tumor growth (Honkanen et al., 2016) |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
Literature references
- Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos.;Haiko Paula, Makinen Taija, Keskitalo Salla, Taipale Jussi, Karkkainen Marika J, Baldwin Megan E, Stacker Steven A, Achen Marc G, Alitalo Kari, ;2008;Molecular and cellular biology;28;4843-50; 18519586
- Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors.;Honkanen Hanne-Kaisa, Izzi Valerio, Petäistö Tiina, Holopainen Tanja, Harjunen Vanessa, Pihlajaniemi Taina, Alitalo Kari, Heljasvaara Ritva, ;2016;Neoplasia (New York, N.Y.);18;436-46; 27435926