MGI phenotypes (allele matching)
- decreased susceptibility to induced arthritis / MGI
FVB.129(Cg)-Bmxtm1Ali/Oulu
| Status | Available to order |
| EMMA ID | EM:09799 |
| Citation information | RRID:IMSR_EM:09799 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | FVB.129(Cg)-Bmxtm1Ali/Oulu |
| Alternative name | Bmx KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Bmxtm1Ali |
| Gene/Transgene symbol | Bmx |
Information from provider
| Provider | Kari Alitalo |
| Provider affiliation | Research Programs Units, University of Helsinki |
| Genetic information | Deletion of the Bmx gene. |
| Phenotypic information | Homozygous:No obvious phenotype in unchallenged knock-out mice (Rajantie et al. 2001). Decreased tumor growth and tumor angiogenesis in several experimental tumor models (Holopainen et al. 2012).Heterozygous:In DMBA-TPA induced skin cancer model: no significant changes between Bmx+/0 and Bmx-/0 males. Increased tumor growth in Bmx+/- females but decreased tumor numbers in Bmx-/- females compared to Bmx+/+ females (Holopainen et al. 2012). |
| Breeding history | Original background DBA/2, backcrossed into C57BL/6 at least 8 times and further into FVB strain at least 5 times. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous FVB males, wild-type FVB females |
| Stage of embryos | 2-cell |
Disease and phenotype information
Literature references
- Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium.;Rajantie I, Ekman N, Iljin K, Arighi E, Gunji Y, Kaukonen J, Palotie A, Dewerchin M, Carmeliet P, Alitalo K, ;2001;Molecular and cellular biology;21;4647-55; 11416142
- Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth.;Holopainen Tanja, López-Alpuche Vanessa, Zheng Wei, Heljasvaara Ritva, Jones Dennis, He Yun, Tvorogov Denis, D'Amico Gabriela, Wiener Zoltan, Andersson Leif C, Pihlajaniemi Taina, Min Wang, Alitalo Kari, ;2012;Cancer research;72;3512-21; 22593188