- increased mortality induced by ionizing radiation / MGI
- immune system phenotype / MGI
- decreased body weight / MGI
- increased mortality induced by gamma-irradiation / MGI
- abnormal inflammatory response / MGI
- decreased litter size / MGI
- abnormal leukocyte migration / MGI
- elevated level of mitotic sister chromatid exchange / MGI
- induced chromosome breakage / MGI
- abnormal cell cycle checkpoint function / MGI
- decreased susceptibility to noise-induced hearing loss / MGI
- increased apoptosis / MGI
- abnormal DNA repair / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- prenatal lethality, incomplete penetrance / MGI
B6.129S2-Parp1tm1Jmdm/Biat
Status | Available to order |
EMMA ID | EM:09855 |
International strain name | B6.129S2-Parp1tm1Jmdm/Biat |
Alternative name | PARP1 |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Parp1tm1Jmdm, |
Gene/Transgene symbol | Parp1 |
Information from provider
Provider | Gilbert de Murcia |
Provider affiliation | UMR7242, CNRS |
Additional owner | Francoise Dantzer and Valérie Schreiber, CNRS-UMR7242, Illkirch, France |
Genetic information | The Parp1 gene has been inactivated by homologous recombination in ES cells from the 129/Sv mouse line by inserting the PGK-neo in exon 4. |
Phenotypic information | Homozygous:The mice display sensitivity to DNA damaging agents (IR, MNU). The mice are viable and fertile.Heterozygous:No phenotype for the heterozygotes. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Breeding at archiving centre | Parp1 (EMMA ID EM:09855) and Parp2 (EMMA ID EM:09858) strains have been imported as refrig. epid.; SF males were produced out of these, sperm frozen and quality-controlled. Therefore prolonged archiving period. |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells.;de Murcia J M, Niedergang C, Trucco C, Ricoul M, Dutrillaux B, Mark M, Oliver F J, Masson M, Dierich A, LeMeur M, Walztinger C, Chambon P, de Murcia G, ;1997;Proceedings of the National Academy of Sciences of the United States of America;94;7303-7; 9207086
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