B6.129S2-Parp1tm1Jmdm/Biat

Status

Available to order

EMMA IDEM:09855
International strain nameB6.129S2-Parp1tm1Jmdm/Biat
Alternative namePARP1
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolParp1tm1Jmdm,
Gene/Transgene symbolParp1

Information from provider

ProviderGilbert de Murcia
Provider affiliationUMR7242, CNRS
Additional ownerFrancoise Dantzer and Valérie Schreiber, CNRS-UMR7242, Illkirch, France
Genetic informationThe Parp1 gene has been inactivated by homologous recombination in ES cells from the 129/Sv mouse line by inserting the PGK-neo in exon 4.
Phenotypic informationHomozygous:
The mice display sensitivity to DNA damaging agents (IR, MNU). The mice are viable and fertile.

Heterozygous:
No phenotype for the heterozygotes.
References
  • Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells.;de Murcia J M, Niedergang C, Trucco C, Ricoul M, Dutrillaux B, Mark M, Oliver F J, Masson M, Dierich A, LeMeur M, Walztinger C, Chambon P, de Murcia G, ;1997;Proceedings of the National Academy of Sciences of the United States of America;94;7303-7; 9207086
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria
Breeding at archiving centreParp1 (EMMA ID EM:09855) and Parp2 (EMMA ID EM:09858) strains have been imported as refrig. epid.; SF males were produced out of these, sperm frozen and quality-controlled. Therefore prolonged archiving period.

Disease and phenotype information

MGI phenotypes (allele matching)
  • increased mortality induced by ionizing radiation / MGI
  • immune system phenotype / MGI
  • decreased body weight / MGI
  • increased mortality induced by gamma-irradiation / MGI
  • abnormal inflammatory response / MGI
  • decreased litter size / MGI
  • abnormal leukocyte migration / MGI
  • elevated level of mitotic sister chromatid exchange / MGI
  • induced chromosome breakage / MGI
  • abnormal cell cycle checkpoint function / MGI
  • decreased susceptibility to noise-induced hearing loss / MGI
  • increased apoptosis / MGI
  • abnormal DNA repair / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • prenatal lethality, incomplete penetrance / MGI

Literature references

  • Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells.;de Murcia J M, Niedergang C, Trucco C, Ricoul M, Dutrillaux B, Mark M, Oliver F J, Masson M, Dierich A, LeMeur M, Walztinger C, Chambon P, de Murcia G, ;1997;Proceedings of the National Academy of Sciences of the United States of America;94;7303-7; 9207086

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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