C57BL/6N-Atm1Brd Tet1tm1a(KOMP)Wtsi/WtsiOrl

Status

Available to order

EMMA IDEM:09888
Citation informationRRID:IMSR_EM:09888 

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International strain nameC57BL/6N-Atm1Brd Tet1tm1a(KOMP)Wtsi/WtsiOrl
Alternative nameEPD0850_2_B07
Strain typeTargeted Mutant Strains
Allele/Transgene symbolTet1tm1a(KOMP)Wtsi
Gene/Transgene symbolTet1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0850_2_B07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NTac males

Disease and phenotype information

MGI phenotypes (gene matching)
  • midline facial cleft / MGI
  • decreased neutrophil cell number / MGI
  • irregular coat pigmentation / MGI
  • abnormal lateral ventricle morphology / MGI
  • incomplete rostral neuropore closure / MGI
  • small ovary / MGI
  • decreased body length / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • ocular hypertelorism / MGI
  • abnormal temporal memory / MGI
  • abnormal embryo development / MGI
  • anencephaly / MGI
  • decreased litter size / MGI
  • abnormal forebrain development / MGI
  • absent ovary / MGI
  • nervous system phenotype / MGI
  • abnormal female reproductive system physiology / MGI
  • abnormal neural tube closure / MGI
  • embryonic growth retardation / MGI
  • decreased ovary weight / MGI
  • abnormal female meiosis / MGI
  • reproductive system phenotype / MGI
  • decreased oocyte number / MGI
  • abnormal interfrontal bone morphology / MGI
  • abnormal paraventricular hypothalamic nucleus morphology / MGI
  • abnormal supraoptic nucleus morphology / MGI
  • abnormal synaptonemal complex / MGI
  • decreased birth body size / MGI
  • increased lipoma incidence / MGI
  • abnormal double-strand DNA break repair / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • preweaning lethality, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • excessive folding of visceral yolk sac / MGI
  • abnormal head fold morphology / MGI
  • encephalomeningocele / MGI
  • impaired spatial learning / MGI
  • abnormal lamina terminalis morphology / MGI
  • bifid nose / MGI

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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