C57BL/6N-Snorctm1a(EUCOMM)Hmgu/Oulu
| Status | Available to order |
| EMMA ID | EM:09933 |
| International strain name | C57BL/6N-Snorctm1a(EUCOMM)Hmgu/Oulu |
| Alternative name | Tuko37 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Snorctm1a(EUCOMM)Hmgu, |
| Gene/Transgene symbol | Snorc |
Information from provider
| Provider | Anna-Marja Säämänen |
| Provider affiliation | Institute of Biomedicine/Department of Medical Biochemistry and Genetics, University of Turku |
| Genetic information | Knock-down of Snorc gene. Snorc is a novel transmembrane proteoglycan particularly expressed in cartilage tissue but also in minor amounts in some other tissues, including lactating mammary gland and prostate. For further details of this proteoglycan see: Heinonen et al. Osteoarthritis Cartilage. 2011 Aug;19(8):1026-35. An ES cell clone containing the Snorc gene targeted by a promoter driven “knock-out first” EUCOMM/KOMP-CSD allele was obtained from the International Knockout Mouse Consortium (IKMC; https://www.mousephenotype.org/data/genes/MGI:1920484#order2) and used for blastocyst injection in C57BL/6NCrl mice for generation of this mouse strain. This is the 10th member of transmembrane proteoglycans and is highly conserved throughout vertebrates. |
| Phenotypic information | Homozygous:Delay in secondary ossification and alterations in trabecular bone structure. Long bones in adults are slightly shorter with some other alterations in the trabecular bone structure. Heterozygous:Not investigated. |
| Breeding history | The strain has been backcrossed over 10 times to the C57BL/6NCrl strain maintained in the animal house of the University of Turku. Sibling matings have been avoided. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | homozygous C57BL/6NCrl, wild-type C57BL/6NCrl |
| Stage of embryos | 2-cell |
Literature references
- Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes.;Heinonen J, Taipaleenmäki H, Roering P, Takatalo M, Harkness L, Sandholm J, Uusitalo-Järvinen H, Kassem M, Kiviranta I, Laitala-Leinonen T, Säämänen A-M, ;2011;Osteoarthritis and cartilage;19;1026-35; 21624478
- Defects in chondrocyte maturation and secondary ossification in mouse knee joint epiphyses due to Snorc deficiency.;Heinonen J, Zhang F-P, Surmann-Schmitt C, Honkala S, Stock M, Poutanen M, Säämänen A-M, ;2017;Osteoarthritis and cartilage;25;1132-1142; 28323137