IMPC phenotypes (gene matching)
C57BL/6-Atm1Brd Lpar1tm1c(EUCOMM)Wtsi/Flmg
| Status | Available to order |
| EMMA ID | EM:09947 |
| Citation information | RRID:IMSR_EM:09947 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Atm1Brd Lpar1tm1c(EUCOMM)Wtsi/Flmg |
| Alternative name | B6-Lpar1 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Lpar1tm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Lpar1 |
Information from provider
| Provider | Vassilis Aidinis |
| Provider affiliation | Institute of Immunology, B.S.R.C. Al. Fleming |
| Genetic information | This allele was derived from the B6-Lpar1tm1a(EUCOMM)Wtsi/Flmg line (EMMA strain EM:09092), by removing the FRT-flanked LacZ and neomycin selection cassette via flp-mediated recombination. The resulting allele has exon 3 (2nd coding exon; ENSMUSE00001261995) flanked by loxP sites providing conditionality. The absence of the LacZ and neomycin cassette was confirmed by PCR. |
| Phenotypic information | Homozygous:No overt phenotype.Heterozygous:No overt phenotype. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous C57BL/6 males |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- abnormal craniofacial morphology / MGI
- short snout / MGI
- exencephaly / MGI
- abnormal Schwann cell morphology / MGI
- decreased Schwann cell number / MGI
- decreased body height / MGI
- decreased body weight / MGI
- decreased body size / MGI
- ocular hypertelorism / MGI
- hypoactivity / MGI
- abnormal suckling behavior / MGI
- postnatal growth retardation / MGI
- increased dopamine level / MGI
- hemorrhage / MGI
- abnormal sciatic nerve morphology / MGI
- nervous system phenotype / MGI
- long incisors / MGI
- abnormal serotonin level / MGI
- abnormal amino acid level / MGI
- decreased body mass index / MGI
- decreased prepulse inhibition / MGI
- decreased total body fat amount / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- decreased body fat mass / MGI
Literature references
- Atx regulates skeletal muscle regeneration via LPAR1 and promotes hypertrophy.;Ray Rashmi, Sinha Sunita, Aidinis Vassilis, Rai Vivek, ;2021;Cell reports;34;108809; 33657371