C57BL/6N-Atm1Brd Apptm1a(KOMP)Wtsi/IcsOrl

Status

Available to order

EMMA IDEM:09980
Citation informationRRID:IMSR_EM:09980 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Atm1Brd Apptm1a(KOMP)Wtsi/IcsOrl
Alternative nameEPD0797_6_F12
Strain typeTargeted Mutant Strains
Allele/Transgene symbolApptm1a(KOMP)Wtsi
Gene/Transgene symbolApp
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from KOMP ES clone EPD0797_6_F12. For further details on the construction of this clone see the page at the IKMC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NTac males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • preweaning lethality, incomplete penetrance / IMPC
  • increased cornea thickness / IMPC
  • decreased total retina thickness / IMPC
  • short tibia / IMPC
  • increased circulating calcium level / IMPC
  • increased blood urea nitrogen level / IMPC
  • decreased grip strength / IMPC
MGI phenotypes (gene matching)
  • amyloidosis / MGI
  • muscle degeneration / MGI
  • decreased corpus callosum size / MGI
  • abnormal telencephalon morphology / MGI
  • decreased body weight / MGI
  • increased anxiety-related response / MGI
  • abnormal locomotor behavior / MGI
  • hyperactivity / MGI
  • hypoactivity / MGI
  • decreased exploration in new environment / MGI
  • abnormal cued conditioning behavior / MGI
  • abnormal spatial learning / MGI
  • reduced long term potentiation / MGI
  • impaired swimming / MGI
  • intracerebral hemorrhage / MGI
  • abnormal learning/memory/conditioning / MGI
  • abnormal fear/anxiety-related behavior / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • premature death / MGI
  • abnormal brain morphology / MGI
  • no abnormal phenotype detected / MGI
  • decreased brain weight / MGI
  • gliosis / MGI
  • absent corpus callosum / MGI
  • abnormal brain commissure morphology / MGI
  • abnormal long term potentiation / MGI
  • abnormal emotion/affect behavior / MGI
  • increased thigmotaxis / MGI
  • abnormal active avoidance behavior / MGI
  • abnormal long term object recognition memory / MGI
  • abnormal neuron morphology / MGI
  • no phenotypic analysis / MGI
  • abnormal locomotor activation / MGI
  • amyloid beta deposits / MGI
  • astrocytosis / MGI
  • nervous system phenotype / MGI
  • impaired passive avoidance behavior / MGI
  • myositis / MGI
  • homeostasis/metabolism phenotype / MGI
  • growth/size/body region phenotype / MGI
  • behavior/neurological phenotype / MGI
  • abnormal cell physiology / MGI
  • decreased hippocampal commissure size / MGI
  • decreased anterior commissure size / MGI
  • abnormal spatial reference memory / MGI
  • hematoma / MGI
  • microgliosis / MGI
  • increased variability of skeletal muscle fiber size / MGI
  • centrally nucleated skeletal muscle fibers / MGI
  • abnormal synapse morphology / MGI
  • decreased grip strength / MGI
  • altered susceptibility to induced thrombosis / MGI
  • abnormal circadian behavior / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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