C57BL/6N-Atm1Brd Rcan1tm1a(KOMP)Wtsi/IcsOrl

Status

Available to order

EMMA IDEM:09983
Citation informationRRID:IMSR_EM:09983 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Atm1Brd Rcan1tm1a(KOMP)Wtsi/IcsOrl
Alternative nameEPD0851_2_D02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolRcan1tm1a(KOMP)Wtsi
Gene/Transgene symbolRcan1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis mouse line originates from KOMP ES clone EPD0851_2_D02. For further details on the construction of this clone see the page at the IKMC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6NTac males

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased lean body mass / IMPC
  • decreased total body fat amount / IMPC
MGI phenotypes (gene matching)
  • abnormal heart morphology / MGI
  • altered response to myocardial infarction / MGI
  • decreased body weight / MGI
  • abnormal adrenal gland secretion / MGI
  • reduced fertility / MGI
  • increased heart weight / MGI
  • decreased heart weight / MGI
  • oxidative stress / MGI
  • decreased response of heart to induced stress / MGI
  • decreased T cell proliferation / MGI
  • abnormal myocardium layer morphology / MGI
  • abnormal circulating protein level / MGI
  • abnormal T-helper 1 physiology / MGI
  • abnormal T cell apoptosis / MGI
  • decreased IgG2a level / MGI
  • decreased interferon-gamma secretion / MGI
  • increased susceptibility to endotoxin shock / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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