INFRAFRONTIER Conference 2026

Scope of the Conference

Over the past decade, researchers in functional genomics and users of in vivo and in vitro models of human health and disease have become increasingly dependent on databases and computational tools. Sequence and annotation repositories, phenotype databases, gene expression atlases, pathway resources, and integrated multi-omics platforms have become indispensable components of daily research practice.

At the same time, increasingly sophisticated analysis pipelines are reshaping how we interpret biological systems. This includes advanced omics integration strategies, machine learning approaches, and AI-based tools capable of extracting information from complex phenotypic and imaging data.

The INFRAFRONTIER Conference 2026 will explore this rapidly evolving landscape and ask a central question: how can we most effectively harness these resources and technologies to advance in silico models of human disease?

Beyond surveying the current state of the art, we will look ahead and address a more ambitious and deliberately provocative question: could in silico disease models one day become as routine and indispensable as the functional and sequence databases we use today? And further: might computational models ultimately reduce, reshape, or even replace parts of experimental disease research? And if so, what evidence and validation standards would justify such a shift?

Crucially, this conference aims not only to discuss algorithms and infrastructures, but also to actively bridge the “wet” experimental side of biomedical research and the “in silico” computational and modeling community. Progress toward robust digital disease models will depend on close interaction between those who generate high-quality experimental data and those who develop the computational frameworks to interpret and simulate them. The meeting therefore seeks to identify shared goals, common benchmarks, and new collaborative strategies that can connect experimental model systems with predictive computational modeling in a productive feedback loop.

About INFRAFRONTIER Conferences

The INFRAFRONTIER Conferences serve as key engagement platforms for the international mouse research community, as well as researchers working in personalised medicine, rare diseases, ageing, functional genetic variants, and cancer research.

Following the success of our previous editions, this year’s event once again offers a unique opportunity for scientific exchange, collaboration, and networking.

Whether you specialise in computational biology, pre-clinical modelling, data integration, or AI applications in reserach, this conference will provide an ideal forum for discussion, networking, and collaboration.

Read more about our last INFRAFRONTIER Conference here.

Join us in Rome to explore the latest breakthroughs in disease modelling and the potential of AI-based approaches!

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