- altered response to myocardial infarction / MGI
- abnormal leukocyte adhesion / MGI
- abnormal cellular extravasation / MGI
- decreased mast cell number / MGI
- decreased susceptibility to type III hypersensitivity reaction / MGI
- abnormal Kupffer cell morphology / MGI
- impaired hematopoiesis / MGI
- abnormal neutrophil physiology / MGI
- granulomatous inflammation / MGI
- increased susceptibility to parasitic infection / MGI
- immune system phenotype / MGI
- increased susceptibility to fungal infection / MGI
B6.129S4-Ccr1tm1Gao/Biat
Status | Available to order |
EMMA ID | EM:11144 |
International strain name | B6.129S4-Ccr1tm1Gao/Biat |
Alternative name | 1-B |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Ccr1tm1Gao |
Gene/Transgene symbol | Ccr1 |
Information from provider
Provider | Bruno Luckow |
Provider affiliation | Nephrologisches Zentrum, Arbeitsgruppe Klinische Biochemie, Klinikum der Universitaet Muenchen, Medizinische Klinik und Poliklinik IV |
Genetic information | The chemokine receptor Ccr1 has been inactivated by homologous recombination. |
Phenotypic information | Homozygous:Homozygous animals appear healthy and fertile and show unchallenged no obvious phenotype. Upregulated in many infectious and inflammatory diseases. Important role in leukocyte chemotaxis and innate immunity. Ccr1-deficient mice show accelerated mortality in an Aspergillus fumigatus infection model and suppression of acute and chronic cardiac allograft rejection. Phenotypic effects in hematopoiesis, host defense and inflammation.Heterozygous:Unknown, but most likely wild-type phenotype |
Breeding history | Initially backcrossed for 6 generations to C57BL/6J and then for other 9 generations to C57BL/6NCrl genetic background. N15+F2 |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | not known |
Information from EMMA
Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Animals used for archiving | homozygous Other (please specify below) |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- decreased mast cell number / MGI
- altered response to myocardial infarction / MGI
- impaired hematopoiesis / MGI
- lung inflammation / MGI
- decreased airway responsiveness / MGI
- decreased susceptibility to viral infection / MGI
- decreased susceptibility to bacterial infection / MGI
- abnormal macrophage physiology / MGI
- abnormal neutrophil physiology / MGI
- granulomatous inflammation / MGI
- glomerulonephritis / MGI
- increased urine protein level / MGI
- abnormal leukocyte adhesion / MGI
- increased length of allograft survival / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- increased susceptibility to parasitic infection / MGI
- glomerulosclerosis / MGI
- abnormal renal glomerulus morphology / MGI
- immune system phenotype / MGI
- increased susceptibility to fungal infection / MGI
- increased blood urea nitrogen level / MGI
- decreased susceptibility to type III hypersensitivity reaction / MGI
- increased susceptibility to type IV hypersensitivity reaction / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- abnormal Kupffer cell morphology / MGI
- increased IgG2a level / MGI
- increased tumor necrosis factor secretion / MGI
- decreased tumor necrosis factor secretion / MGI
- increased interferon-gamma secretion / MGI
- decreased circulating interferon-gamma level / MGI
- decreased interleukin-10 secretion / MGI
- increased interleukin-12 secretion / MGI
- decreased interleukin-13 secretion / MGI
- impaired neutrophil recruitment / MGI
- abnormal chemokine secretion / MGI
- cecum inflammation / MGI
- decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
- abnormal cellular extravasation / MGI
- abnormal circulating chemokine level / MGI
- increased macrophage nitric oxide production / MGI
- glomerular crescent / MGI
Literature references
- Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1.;Gao J L, Wynn T A, Chang Y, Lee E J, Broxmeyer H E, Cooper S, Tiffany H L, Westphal H, Kwon-Chung J, Murphy P M, ;1997;The Journal of experimental medicine;185;1959-68; 9166425
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