| Status | Available to order |
| EMMA ID | EM:12807 |
| International strain name | STOCK Slamf1tm1Oono Ifnar1tm1Agt/Biat |
| Alternative name | IFNAR-/- SLAM KI |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ifnar1tm1Agt, Slamf1tm1Oono |
| Gene/Transgene symbol | Ifnar1, Slamf1 |
| Provider | Roland Plesker |
| Provider affiliation | Section 4/ZT-Central Animal husbandry, Paul-Ehrlich-Institut |
| Additional owner | Yusuke Yanagi, M.D., Ph.D., Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka, Japan |
| Genetic information | Exon 2 encoding the V domain of mouse Slamf1 (Slam) gene replaced by human SLAM (Ohno S. et al., J Virol., 2007). Murine Ifnar1 gene targeted by germline transmission of disrupted allele (Müller U. et al., Science, 1994). |
| Phenotypic information | Homozygous:IFNAR knock-out: abnormal lymphopoiesis, increased susceptibility to viral infection. SLAM knock-in: increased susceptibility of lymphocytic cells to Measles virus.Heterozygous:IFNAR knock-out: none SLAM knock-in: increased susceptibility of lymphocytic cells to Measles virus. |
| Breeding history | Bred to homozygosity. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | homozygous B6.129-Slamf1tm1Oono Ifnar1tm1Agt, homozygous B6.129-Slamf1tm1Oono Ifnar1tm1Agt |
| Breeding at archiving centre | Sent animals were rederived to the SPF area (barrier) and a colony was built. This colony was used for Speed Cryo IVF and embryo freezing (slow) of double homozygous embryos. |
| Stage of embryos | 2-cell |
