IMPC phenotypes (gene matching)
B6.Cg-Il6tm2.1Jho/Cnbc
| Status | Available to order |
| EMMA ID | EM:13231 |
| International strain name | B6.Cg-Il6tm2.1Jho/Cnbc |
| Alternative name | IL6-DIO-KO (Il6 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Il6tm2.1Jho |
| Gene/Transgene symbol | Il6 |
Information from provider
| Provider | Juan Hidalgo |
| Provider affiliation | Biologia Celular, Fisiologia e Inmunologia, Universidad Autonoma de Barcelona |
| Genetic information | The gene is interleukin 6 (Il6). This is a conditional reversible Il6 knock-out (IL6-DIO-KO) mouse line that was developed using double-inverted open reading frame (DIO) technology. |
| Phenotypic information | Homozygous:The animal will be systemic Il6 knock-out (which can be reactivated by cre recombinase). In normal conditions will breed normally and there is no obvious phenotype. A clear phenotype will be appearing in specific experimental settings. For instance, the mice will be resistant to the experimental autoimmune encephalomyelitis (EAE) multiple sclerosis model.Heterozygous:The animal will have one wild-type Il6 allele and a null allele. |
| Breeding history | The mutant mice have been backcrossed >10 times to C57BL/6OlaHsd mice. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6JOlaHsd |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- abnormal trabecular bone morphology / MGI
- decreased compact bone thickness / MGI
- abnormal microglial cell morphology / MGI
- abnormal heart morphology / MGI
- abnormal heart development / MGI
- thin ventricular wall / MGI
- abnormal interventricular septum morphology / MGI
- abnormal liver morphology / MGI
- abnormal lymphocyte cell number / MGI
- abnormal CNS glial cell morphology / MGI
- abnormal body weight / MGI
- obese / MGI
- decreased body weight / MGI
- increased aggression towards males / MGI
- abnormal social investigation / MGI
- increased anxiety-related response / MGI
- abnormal stationary movement / MGI
- hyperactivity / MGI
- abnormal object recognition memory / MGI
- abnormal spatial learning / MGI
- abnormal sleep pattern / MGI
- abnormal osteoclast physiology / MGI
- abnormal cardiovascular system physiology / MGI
- hepatic necrosis / MGI
- abnormal homeostasis / MGI
- abnormal immune system physiology / MGI
- impaired wound healing / MGI
- decreased IgA level / MGI
- abnormal inflammatory response / MGI
- brain inflammation / MGI
- decreased inflammatory response / MGI
- abnormal dopamine level / MGI
- decreased chemically-elicited antinociception / MGI
- decreased incidence of induced tumors / MGI
- abnormal learning/memory/conditioning / MGI
- seizures / MGI
- abnormal glucose homeostasis / MGI
- abnormal T cell differentiation / MGI
- abnormal astrocyte morphology / MGI
- gliosis / MGI
- abnormal exercise endurance / MGI
- abnormal pulmonary gas exchange / MGI
- increased susceptibility to bacterial infection / MGI
- increased susceptibility to viral infection / MGI
- abnormal T-helper 1 cell morphology / MGI
- abnormal T cell physiology / MGI
- abnormal macrophage physiology / MGI
- abnormal neutrophil physiology / MGI
- decreased IgE level / MGI
- abnormal emotion/affect behavior / MGI
- behavioral despair / MGI
- decreased glucagon secretion / MGI
- abnormal mechanical nociception / MGI
- dilated heart left ventricle / MGI
- abnormal passive avoidance behavior / MGI
- abnormal long term object recognition memory / MGI
- decreased heart weight / MGI
- abnormal neuron morphology / MGI
- delayed wound healing / MGI
- abnormal bone remodeling / MGI
- abnormal bone healing / MGI
- decreased insulin secretion / MGI
- abnormal skeletal muscle fiber morphology / MGI
- abnormal muscle precursor cell migration / MGI
- liver degeneration / MGI
- abnormal frequency of paradoxical sleep / MGI
- liver failure / MGI
- decreased susceptibility to induced arthritis / MGI
- increased fear-related response / MGI
- abnormal nervous system physiology / MGI
- abnormal glial cell morphology / MGI
- abnormal capillary morphology / MGI
- abnormal microglial cell physiology / MGI
- impaired febrile response / MGI
- abnormal brain interneuron morphology / MGI
- decreased incidence of tumors by chemical induction / MGI
- abnormal neuron physiology / MGI
- abnormal behavior / MGI
- decreased T cell number / MGI
- increased susceptibility to parasitic infection / MGI
- decreased cytotoxic T cell cytolysis / MGI
- decreased cardiac muscle contractility / MGI
- abnormal B cell proliferation / MGI
- decreased susceptibility to injury / MGI
- abnormal oxygen consumption / MGI
- impaired glucose tolerance / MGI
- abnormal heart ventricle morphology / MGI
- homeostasis/metabolism phenotype / MGI
- growth/size/body region phenotype / MGI
- behavior/neurological phenotype / MGI
- immune system phenotype / MGI
- increased susceptibility to fungal infection / MGI
- abnormal axon morphology / MGI
- abnormal food intake / MGI
- abnormal T-helper 1 physiology / MGI
- abnormal T-helper 2 physiology / MGI
- decreased liver regeneration / MGI
- increased body temperature / MGI
- increased circulating glucose level / MGI
- decreased dopamine level / MGI
- abnormal involution of the mammary gland / MGI
- absent NK cells / MGI
- decreased pro-B cell number / MGI
- abnormal osteoblast differentiation / MGI
- abnormal osteoclast differentiation / MGI
- increased IgG2a level / MGI
- retinal outer nuclear layer degeneration / MGI
- increased susceptibility to induced colitis / MGI
- decreased interferon-gamma secretion / MGI
- increased circulating interleukin-10 level / MGI
- decreased circulating interleukin-12 level / MGI
- decreased interleukin-17 secretion / MGI
- increased interleukin-4 secretion / MGI
- abnormal interleukin-6 secretion / MGI
- impaired neutrophil recruitment / MGI
- abnormal interferon level / MGI
- abnormal skeletal muscle satellite cell proliferation / MGI
- enhanced behavioral response to morphine / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- abnormal oval cell physiology / MGI
- abnormal bone mineral density / MGI
- abnormal acute phase protein level / MGI
- mortality/aging / MGI
- increased susceptibility to dopaminergic neuron neurotoxicity / MGI
- abnormal substantia nigra pars compacta morphology / MGI
- abnormal inhibitory learning / MGI
- abnormal pancreatic alpha cell mass / MGI
Literature references
- A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner: microglial IL-6 regulation of experimental autoimmune encephalomyelitis.;Sanchis Paula, Fernández-Gayol Olaya, Comes Gemma, Aguilar Kevin, Escrig Anna, Giralt Mercedes, Palmiter Richard D, Hidalgo Juan, ;2020;Journal of neuroinflammation;17;304; 33059703