MGI phenotypes (allele matching)
- abnormal glucose homeostasis / MGI
NOD.B6-(D17Mit113-D17Mit199)/GhjOrl
| Status | Available to order |
| EMMA ID | EM:01399 |
| International strain name | NOD.B6-(D17Mit113-D17Mit199)/GhjOrl |
| Alternative name | NOD.B6-C17(R114) |
| Strain type | Other |
| Allele/Transgene symbol | Idd23C57BL/6J, Ceat1C57BL/6J |
| Gene/Transgene symbol | Idd23, Ceat1, Idd16 |
Information from provider
| Provider | Henri-Jean Garchon |
| Provider affiliation | ER70 CNRS et Unite 125 Inserm |
| Genetic information | NOD congenic strain with an interval proximal to the H2 complex from C57BL/6. The R114 interval includes the Idd16 and Ceat1 loci but excludes the Idd1 locus and the H2 complex proper. |
| Phenotypic information | This line and the related lines, consomic, congenic and subcongenic for chromosome 17 and fragments of this chromosome, were derived to thoroughly investigate the role of the major histocompatibility complex (MHC) and MHC-linked genes in autoimmune predisposition, notably including type I diabetes (Idd1 and Idd16) loci and chronic autoimmune thyroiditis (Ceat1) locus), on the non-obese diabetic (NOD) background. The R114 line is completely protected against type 1 diabetes and autoimmune thyroiditis. |
| Breeding history | 20 generations of backcrosses followed by sister-brother matings. Selection of subcongenics by additional backcrosses. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Literature references
- An interval tightly linked to but distinct from the H2 complex controls both overt diabetes (Idd16) and chronic experimental autoimmune thyroiditis (Ceat1) in nonobese diabetic mice.;Boulard Olivier, Damotte Diane, Deruytter Nathalie, Fluteau Guy, Carnaud Claude, Garchon Henri-Jean, ;2002;Diabetes;51;2141-7; 12086944
- Mapping non-class II H2-linked loci for type 1 diabetes in nonobese diabetic mice.;Deruytter Nathalie, Boulard Olivier, Garchon Henri-Jean, ;2004;Diabetes;53;3323-7; 15561967