C.Cg-Tg(Tcrb-LMR16.2)1Nglh/Orl
| Status | Available to order |
| EMMA ID | EM:01423 |
| International strain name | C.Cg-Tg(Tcrb-LMR16.2)1Nglh/Orl |
| Alternative name | 16.2 beta |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Tcrb-LMR16.2)1Nglh |
| Gene/Transgene symbol | Tg(Tcrb-LMR16.2)1Nglh |
Information from provider
| Provider | Nicolas Glaichenhaus |
| Provider affiliation | INSERM U561 - Hopital Saint Vincent de Paul, Paris |
| Genetic information | Mice were made transgenic for a T-cell receptor directed to an antigen (Leishmania activated c kinase: LACK) from the Leishmania parasite. |
| Phenotypic information | These mice provide a good model to study leishmaniasis since the frequency of CD4+ T cells recognizing an antigen (LACK) from the Leishmania parasite is increased up to 1%. With this frequency, it is possible to follow the immune response to the parasite in both resistant (B10D2) and susceptible (BALB/c) strains. |
| Breeding history | The mice were backcrossed for 10 generations to the susceptible BALB/c and to the resistant B10D2 background. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Literature references
- Selective activation and expansion of high-affinity CD4+ T cells in resistant mice upon infection with Leishmania major.;Malherbe L, Filippi C, Julia V, Foucras G, Moro M, Appel H, Wucherpfennig K, Guéry J C, Glaichenhaus N, ;2000;Immunity;13;771-82; 11163193
- Blockade of CD86 in BALB/c mice infected with Leishmania major does not prevent the expansion of low avidity T cells.;Moro Monica, Filippi Christophe, Gallard Alexandra, Malherbe Laurent, Foucras Gilles, Akiba Hisaya, Yagita Hideo, Guéry Jean-Charles, Glaichenhaus Nicolas, ;2002;European journal of immunology;32;3566-75; 12516542