IMPC phenotypes (gene matching)
B6.Cg-Nfat5tm1.1Joar/Cnbc
| Status | Available to order |
| EMMA ID | EM:15109 |
| International strain name | B6.Cg-Nfat5tm1.1Joar/Cnbc |
| Alternative name | NFAT5 floxed mice |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Nfat5tm1.1Joar |
| Gene/Transgene symbol | Nfat5 |
Information from provider
| Provider | Cristina Lopez Rodriguez |
| Provider affiliation | Universitat Pompeu Fabra |
| Genetic information | Exon 6 of the Nfat5 gene was flanked by loxP sites by homologous recombination in C57BL/6-derived embryonic stem cells (Bruce 4). Original reference: Drews-Elger et al. PLoS One, 2009. |
| Phenotypic information | Homozygous:No obvious phenotype unless immune responses are induced. The full Nfat5 knock-out is expected to be embryonic lethal in the C57BL/6 genetic background. Nfat5 floxed mice are healthy, with no phenotype. In our hands, conditional Nfat5 knock-outs in different immune cell subtypes are healthy. Heterozygous:No observed phenotype. |
| Breeding history | Mutant mice were generated by homologous recombination in C57BL/6-derived embryonic stem cells (Bruce 4) and performing several backcrosses (more than 10 generations) to C57BL/6. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Disease and phenotype information
Literature references
- The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress.;Drews-Elger Katherine, Ortells M Carmen, Rao Anjana, López-Rodriguez Cristina, Aramburu Jose, ;2009;PloS one;4;e5245; 19381288
- NFAT5 Controls the Integrity of Epidermis.;Muhammad Khalid, Xavier Delicia, Klein-Hessling Stefan, Azeem Muhammad, Rauschenberger Tabea, Murti Krisna, Avots Andris, Goebeler Matthias, Klein Matthias, Bopp Tobias, Sielaff Malte, Tenzer Stefan, Möckel Sigrid, Aramburu José, López-Rodríguez Cristina, Kerstan Andreas, Serfling Edgar, ;2021;Frontiers in immunology;12;780727; 34956208
- Salt-Sensitive Hypertension of the Renal Tubular Cell-Specific NFAT5 (Nuclear Factor of Activated T-Cells 5) Knockout Mice.;Hiramatsu Akiko, Izumi Yuichiro, Eguchi Koji, Matsuo Naomi, Deng Qinyuan, Inoue Hideki, Nakayama Yushi, Nonoguchi Hiroshi, Aramburu Jose, López-Rodríguez Cristina, Kakizoe Yutaka, Adachi Masataka, Kuwabara Takashige, Kim-Mitsuyama Shokei, Mukoyama Masashi, ;2021;Hypertension (Dallas, Tex. : 1979);78;1335-1346; 34601973
- The transcription factor NFAT5 limits infection-induced type I interferon responses.;Huerga Encabo Hector, Traveset Laia, Argilaguet Jordi, Angulo Ana, Nistal-Villán Estanislao, Jaiswal Rahul, Escalante Carlos R, Gekas Christos, Meyerhans Andreas, Aramburu Jose, López-Rodríguez Cristina, ;2020;The Journal of experimental medicine;217;2901-2918; 31816635
- Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5.;Buxadé Maria, Huerga Encabo Hector, Riera-Borrull Marta, Quintana-Gallardo Lucía, López-Cotarelo Pilar, Tellechea Mónica, Martínez-Martínez Sara, Redondo Juan Miguel, Martín-Caballero Juan, Flores Juana María, Bosch Elena, Rodríguez-Fernández José Luis, Aramburu Jose, López-Rodríguez Cristina, ;2018;The Journal of experimental medicine;215;101; 30327417
- Analgesia linked to Nav1.7 loss of function requires µ- and δ-opioid receptors.;Pereira Vanessa, Millet Queensta, Aramburu Jose, Lopez-Rodriguez Cristina, Gaveriaux-Ruff Claire, Wood John N, ;2018;Wellcome open research;3;305-315; 30271888
- NFAT5-Regulated Macrophage Polarization Supports the Proinflammatory Function of Macrophages and T Lymphocytes.;Tellechea Mónica, Buxadé Maria, Tejedor Sonia, Aramburu Jose, López-Rodríguez Cristina, ;2018;Journal of immunology (Baltimore, Md. : 1950);200;56-67; 29150563
- Context-dependent regulation of Th17-associated genes and IFNγ expression by the transcription factor NFAT5.;Alberdi Maria, Iglesias Marcos, Tejedor Sonia, Merino Ramón, López-Rodríguez Cristina, Aramburu Jose, ;2017;Immunology and cell biology;95;; 27479742