B6.129-Cd247tm1Lov Fcer1gtm1Rav Rag1tm1Mom Tyrobptm1.1Viv/Orl

Status

Available to order

EMMA IDEM:01790
International strain nameB6.129-Cd247tm1Lov Fcer1gtm1Rav Rag1tm1Mom Tyrobptm1.1Viv/Orl
Alternative nameZGKR
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolTyrobptm1.1Viv, Cd247tm1Lov, Fcer1gtm1Rav, Rag1tm1Mom
Gene/Transgene symbolTyrobp, Cd247, Fcer1g, Rag1

Information from provider

ProviderElena Tomasello
Provider affiliationU136, CIML
Genetic informationCD3zeta (Cd247), FcRg (Fcer1g) and Rag1 gene expression has been completely inactivated by homologous recombination. DAP12 (Tyrobp) gene presents a loss-of-function mutation.
Phenotypic informationDeficiency in natural killer cell function.
Breeding history8 backcrosses to C57BL/6.
References
  • Multiplicity and plasticity of natural killer cell signaling pathways.;Chiesa Sabrina, Mingueneau Michael, Fuseri Nicolas, Malissen Bernard, Raulet David H, Malissen Marie, Vivier Eric, Tomasello Elena, ;2006;Blood;107;2364-72; 16291591

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • preweaning lethality, incomplete penetrance / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • decreased mean corpuscular volume / IMPC
MGI phenotypes (allele matching)
  • reduced long term depression / MGI
  • abnormal long term depression / MGI
  • enhanced long term potentiation / MGI
  • abnormal lateral geniculate nucleus morphology / MGI
  • enlarged lateral ventricles / MGI
  • decreased thymocyte number / MGI
  • abnormal superior colliculus morphology / MGI
  • absent long term depression / MGI
  • abnormal brain morphology / MGI
  • abnormal CNS synaptic transmission / MGI
  • abnormal T-helper 1 cell morphology / MGI
  • abnormal excitatory postsynaptic potential / MGI
  • decreased double-positive T cell number / MGI
  • abnormal T-helper 1 physiology / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • abnormal single-positive T cell number / MGI
  • absent gamma-delta intraepithelial T cell / MGI
  • immune system phenotype / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interleukin-1 beta secretion / MGI
  • decreased interleukin-10 secretion / MGI
  • decreased interleukin-12b secretion / MGI
  • decreased interleukin-23 secretion / MGI
  • decreased interleukin-6 secretion / MGI
  • abnormal hemoglobin / MGI
  • increased susceptibility to parasitic infection / MGI
  • skeleton phenotype / MGI
  • hematoma / MGI
  • decreased platelet aggregation / MGI
  • impaired macrophage phagocytosis / MGI
  • abnormal immune cell physiology / MGI
  • abnormal mast cell physiology / MGI
  • abnormal dendritic cell antigen presentation / MGI
  • abnormal immunoglobulin level / MGI
  • increased IgE level / MGI
  • decreased myocardial infarction size / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • decreased platelet calcium level / MGI
  • decreased susceptibility to type I hypersensitivity reaction / MGI
  • abnormal platelet activation / MGI
  • abnormal NK cell physiology / MGI
  • increased granulocyte number / MGI
  • spleen hypoplasia / MGI
  • decreased immunoglobulin level / MGI
  • abnormal level of surface class II molecules / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • increased macrophage cell number / MGI
  • increased NK cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased mature B cell number / MGI
  • increased immature B cell number / MGI
  • scaly skin / MGI
  • dermatitis / MGI
  • thick skin / MGI
  • epidermal hyperplasia / MGI
  • mixed cellular infiltration to dermis / MGI
  • decreased IgM level / MGI
  • ear inflammation / MGI
  • decreased vascular permeability / MGI
  • increased eosinophil cell number / MGI
  • decreased neutrophil cell number / MGI
  • abnormal retina morphology / MGI
  • autoimmune response / MGI
  • abnormal lymphatic vessel morphology / MGI
  • abnormal coat/hair pigmentation / MGI
  • abnormal eye morphology / MGI
  • abnormal skin pigmentation / MGI
  • abnormal respiratory system morphology / MGI
  • abnormal response to infection / MGI
  • decreased susceptibility to induced colitis / MGI
  • thymus hypoplasia / MGI
  • abnormal B cell differentiation / MGI
  • abnormal T cell differentiation / MGI
  • abnormal inguinal lymph node morphology / MGI
  • nervous system phenotype / MGI
  • behavior/neurological phenotype / MGI
  • abnormal T cell morphology / MGI
  • absent mature B cells / MGI
  • abnormal T cell receptor V(D)J recombination / MGI
  • abnormal immunoglobulin V(D)J recombination / MGI
  • decreased inflammatory response / MGI
  • abnormal double-negative T cell morphology / MGI
  • abnormal thymus epithelium morphology / MGI
  • abnormal neuron proliferation / MGI
  • small thymus / MGI
  • decreased lymphocyte cell number / MGI
  • abnormal bone remodeling / MGI
  • increased bone mineral density / MGI
  • osteopetrosis / MGI
  • abnormal microglial cell morphology / MGI
  • abnormal myelination / MGI
  • abnormal osteoclast physiology / MGI
  • abnormal myelopoiesis / MGI
  • abnormal excitatory postsynaptic currents / MGI
  • decreased bone resorption / MGI
  • abnormal axon morphology / MGI
  • increased bone mass / MGI
  • abnormal bone ossification / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • increased bone mineral content / MGI
  • increased bone trabecula number / MGI
  • increased trabecular bone volume / MGI
  • failure of embryo implantation / MGI
  • reduced fertility / MGI
  • abnormal maternal decidual layer morphology / MGI
  • enlarged placenta / MGI
  • decreased uterine NK cell number / MGI
  • abnormal decidua basalis morphology / MGI
  • abnormal uterine spiral artery morphology / MGI
  • abnormal uterine spiral artery remodeling / MGI
  • decreased susceptibility to type IV hypersensitivity reaction / MGI
  • increased dendritic cell number / MGI
MGI phenotypes (gene matching)
  • enlarged spleen / MGI
  • enlarged lymph nodes / MGI
  • small thymus / MGI
  • decreased thymocyte number / MGI
  • abnormal superior colliculus morphology / MGI
  • reduced long term depression / MGI
  • thymus hypoplasia / MGI
  • abnormal long term depression / MGI
  • absent long term depression / MGI
  • abnormal T cell differentiation / MGI
  • abnormal brain morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal CNS synaptic transmission / MGI
  • abnormal double-negative T cell morphology / MGI
  • abnormal T-helper 1 cell morphology / MGI
  • abnormal T cell physiology / MGI
  • abnormal excitatory postsynaptic potential / MGI
  • enhanced long term potentiation / MGI
  • increased natural killer cell mediated cytotoxicity / MGI
  • abnormal thymocyte activation / MGI
  • abnormal lateral geniculate nucleus morphology / MGI
  • increased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • abnormal regulatory T cell physiology / MGI
  • increased regulatory T cell number / MGI
  • abnormal NK cell morphology / MGI
  • increased double-negative T cell number / MGI
  • decreased double-positive T cell number / MGI
  • abnormal T cell proliferation / MGI
  • decreased T cell proliferation / MGI
  • immune system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • abnormal T-helper 1 physiology / MGI
  • abnormal NK T cell morphology / MGI
  • abnormal T cell morphology / MGI
  • decreased NK T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • abnormal single-positive T cell number / MGI
  • decreased single-positive T cell number / MGI
  • abnormal T-helper 1 cell differentiation / MGI
  • absent gamma-delta intraepithelial T cell / MGI
  • abnormal gamma-delta T cell differentiation / MGI
  • abnormal alpha-beta intraepithelial T cell morphology / MGI
  • enlarged lateral ventricles / MGI
  • increased interferon-gamma secretion / MGI
  • abnormal intraepithelial T cell morphology / MGI
  • abnormal bone marrow cell physiology / MGI
  • decreased splenocyte proliferation / MGI
  • decreased thymocyte apoptosis / MGI
  • abnormal NK cell physiology / MGI
  • postnatal lethality, complete penetrance / MGI
  • small thymus medulla / MGI
  • enlarged thymus cortex / MGI
  • abnormal hemoglobin / MGI
  • impaired macrophage phagocytosis / MGI
  • decreased IgG level / MGI
  • abnormal immune cell physiology / MGI
  • abnormal antigen presentation / MGI
  • decreased inflammatory response / MGI
  • abnormal mast cell physiology / MGI
  • abnormal macrophage physiology / MGI
  • abnormal dendritic cell antigen presentation / MGI
  • abnormal immunoglobulin level / MGI
  • increased IgE level / MGI
  • decreased myocardial infarction size / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • decreased susceptibility to autoimmune hemolytic anemia / MGI
  • decreased platelet calcium level / MGI
  • increased susceptibility to parasitic infection / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • decreased T cell proliferation / MGI
  • immune system phenotype / MGI
  • skeleton phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • decreased susceptibility to type I hypersensitivity reaction / MGI
  • decreased susceptibility to type IV hypersensitivity reaction / MGI
  • abnormal platelet activation / MGI
  • abnormal NK T cell physiology / MGI
  • decreased dendritic cell number / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • decreased IgG2b level / MGI
  • decreased IgG3 level / MGI
  • abnormal interferon-gamma secretion / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interferon-gamma secretion / MGI
  • decreased interleukin-1 beta secretion / MGI
  • decreased interleukin-10 secretion / MGI
  • decreased interleukin-12b secretion / MGI
  • abnormal interleukin-17 secretion / MGI
  • decreased interleukin-2 secretion / MGI
  • decreased interleukin-23 secretion / MGI
  • decreased interleukin-6 secretion / MGI
  • abnormal chemokine secretion / MGI
  • hematoma / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • decreased platelet aggregation / MGI
  • decreased sensitivity to induced morbidity/mortality / MGI
  • decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • abnormal NK cell physiology / MGI
  • decreased neutrophil cell number / MGI
  • increased granulocyte number / MGI
  • spleen hypoplasia / MGI
  • small thymus / MGI
  • absent lymphocyte / MGI
  • scaly skin / MGI
  • dermatitis / MGI
  • thick skin / MGI
  • epidermal hyperplasia / MGI
  • mixed cellular infiltration to dermis / MGI
  • abnormal retina morphology / MGI
  • arrested B cell differentiation / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • thymus hypoplasia / MGI
  • arrested T cell differentiation / MGI
  • autoimmune response / MGI
  • ear inflammation / MGI
  • decreased inflammatory response / MGI
  • abnormal lymphatic vessel morphology / MGI
  • abnormal coat/hair pigmentation / MGI
  • abnormal eye morphology / MGI
  • abnormal skin pigmentation / MGI
  • abnormal respiratory system morphology / MGI
  • abnormal B cell differentiation / MGI
  • abnormal T cell differentiation / MGI
  • abnormal inguinal lymph node morphology / MGI
  • abnormal lymphopoiesis / MGI
  • abnormal double-negative T cell morphology / MGI
  • abnormal double-positive T cell morphology / MGI
  • decreased immunoglobulin level / MGI
  • abnormal immunoglobulin level / MGI
  • abnormal bone remodeling / MGI
  • decreased vascular permeability / MGI
  • nervous system phenotype / MGI
  • spontaneous chromosome breakage / MGI
  • abnormal class switch recombination / MGI
  • increased eosinophil cell number / MGI
  • decreased lymphocyte cell number / MGI
  • decreased B cell number / MGI
  • decreased T cell number / MGI
  • abnormal response to infection / MGI
  • abnormal level of surface class II molecules / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • increased double-negative T cell number / MGI
  • decreased double-positive T cell number / MGI
  • behavior/neurological phenotype / MGI
  • skeleton phenotype / MGI
  • increased macrophage cell number / MGI
  • absent late pro-B cells / MGI
  • abnormal T cell morphology / MGI
  • increased NK cell number / MGI
  • absent T cells / MGI
  • absent B cells / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • increased pro-B cell number / MGI
  • decreased mature B cell number / MGI
  • absent mature B cells / MGI
  • absent immature B cells / MGI
  • increased immature B cell number / MGI
  • decreased gamma-delta T cell number / MGI
  • decreased susceptibility to induced colitis / MGI
  • abnormal T cell receptor V(D)J recombination / MGI
  • abnormal immunoglobulin V(D)J recombination / MGI
  • abnormal T cell receptor beta chain V(D)J recombination / MGI
  • abnormal immunoglobulin heavy chain V(D)J recombination / MGI
  • abnormal thymus epithelium morphology / MGI
  • abnormal neuron proliferation / MGI
  • increased bone mineral density / MGI
  • osteopetrosis / MGI
  • abnormal microglial cell morphology / MGI
  • abnormal myelination / MGI
  • abnormal oligodendrocyte morphology / MGI
  • decreased startle reflex / MGI
  • abnormal osteoclast physiology / MGI
  • abnormal myelopoiesis / MGI
  • failure of embryo implantation / MGI
  • reduced fertility / MGI
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to viral infection / MGI
  • reduced sensorimotor gating / MGI
  • abnormal neuron morphology / MGI
  • abnormal excitatory postsynaptic currents / MGI
  • abnormal inhibitory postsynaptic currents / MGI
  • abnormal bone remodeling / MGI
  • enhanced long term potentiation / MGI
  • increased natural killer cell mediated cytotoxicity / MGI
  • decreased susceptibility to induced arthritis / MGI
  • nervous system phenotype / MGI
  • increased autoantibody level / MGI
  • abnormal maternal decidual layer morphology / MGI
  • enlarged placenta / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • abnormal osteoclast morphology / MGI
  • decreased bone resorption / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • decreased T cell proliferation / MGI
  • increased B cell proliferation / MGI
  • behavior/neurological phenotype / MGI
  • immune system phenotype / MGI
  • skeleton phenotype / MGI
  • abnormal axon morphology / MGI
  • increased bone mass / MGI
  • decreased susceptibility to type IV hypersensitivity reaction / MGI
  • abnormal NK T cell physiology / MGI
  • increased dendritic cell number / MGI
  • increased germinal center B cell number / MGI
  • abnormal bone ossification / MGI
  • abnormal osteoclast differentiation / MGI
  • increased spleen germinal center number / MGI
  • increased spleen germinal center size / MGI
  • increased IgG2a level / MGI
  • increased IgG3 level / MGI
  • decreased interferon-gamma secretion / MGI
  • increased interleukin-6 secretion / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • decreased uterine NK cell number / MGI
  • decreased prepulse inhibition / MGI
  • increased bone mineral content / MGI
  • increased bone trabecula number / MGI
  • increased trabecular bone mass / MGI
  • increased trabecular bone volume / MGI
  • abnormal decidua basalis morphology / MGI
  • abnormal uterine spiral artery morphology / MGI
  • abnormal uterine spiral artery remodeling / MGI

Literature references

  • Multiplicity and plasticity of natural killer cell signaling pathways.;Chiesa Sabrina, Mingueneau Michael, Fuseri Nicolas, Malissen Bernard, Raulet David H, Malissen Marie, Vivier Eric, Tomasello Elena, ;2006;Blood;107;2364-72; 16291591

Information on how we integrate external resources can be found here

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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