C57BL/6RccCnrm

Status

Available to order

EMMA IDEM:01999
International strain nameC57BL/6RccCnrm
Alternative nameC57 BL/6RCC
Strain typeOther
Allele/Transgene symbolCd44+
Gene/Transgene symbolCd44

Information from provider

ProviderUrsula Günthert
Provider affiliationInstitut für Pathologie, University of Basel
Genetic informationThe C57BL/6Rcc (B6Rcc) mice are the reference strain for EAE experiments with B6Rcc CD44v6v7-/-, B6Rcc CD44v7-/-, B6Rcc CD44v10-/-, B6Rcc CD44v6v7-/- OPN-/-, B6Rcc CD44v7-/- OPN-/-, B6Rcc CD44v10-/- OPN-/-. Also for bone marrow transplantation with B6Rcc Ly5.1.
Phenotypic informationC57BL/6Rcc mice are highly susceptible for active immunization with MOG (myelin oligodendrocyte glycoprotein) peptides to induce experimental autoimmune encephalomyelitis (EAE).
Breeding historyCurrently bred as C57BL/6Rcc.
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (gene matching)
  • decreased mast cell number / MGI
  • altered response to myocardial infarction / MGI
  • abnormal cell morphology / MGI
  • decreased mast cell histamine storage / MGI
  • abnormal uterus morphology / MGI
  • thin epidermis / MGI
  • abnormal lipid level / MGI
  • abnormal vasculogenesis / MGI
  • abnormal digestive system physiology / MGI
  • impaired wound healing / MGI
  • impaired macrophage phagocytosis / MGI
  • liver inflammation / MGI
  • lung inflammation / MGI
  • abnormal definitive hematopoiesis / MGI
  • no abnormal phenotype detected / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal neutrophil physiology / MGI
  • short tibia / MGI
  • impaired skin barrier function / MGI
  • delayed wound healing / MGI
  • decreased myocardial infarction size / MGI
  • abnormal leukocyte migration / MGI
  • peritoneal inflammation / MGI
  • decreased susceptibility to induced arthritis / MGI
  • decreased tumor growth/size / MGI
  • abnormal leukocyte adhesion / MGI
  • abnormal physiological neovascularization / MGI
  • increased susceptibility to induced arthritis / MGI
  • enhanced coordination / MGI
  • decreased cholesterol level / MGI
  • abnormal vascular endothelial cell physiology / MGI
  • decreased susceptibility to kidney reperfusion injury / MGI
  • abnormal miniature excitatory postsynaptic currents / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • increased mean systemic arterial blood pressure / MGI
  • abnormal CD8-positive, alpha beta T cell morphology / MGI
  • abnormal response to infection / MGI
  • increased susceptibility to parasitic infection / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • decreased acute inflammation / MGI
  • increased acute inflammation / MGI
  • decreased T cell proliferation / MGI
  • digestive/alimentary phenotype / MGI
  • immune system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • abnormal T-helper 1 physiology / MGI
  • abnormal T-helper 2 physiology / MGI
  • choroidal neovascularization / MGI
  • decreased circulating creatinine level / MGI
  • decreased blood urea nitrogen level / MGI
  • abnormal vascular smooth muscle physiology / MGI
  • decreased angiogenesis / MGI
  • decreased susceptibility to type IV hypersensitivity reaction / MGI
  • abnormal cell physiology / MGI
  • abnormal vascular endothelial cell morphology / MGI
  • abnormal involution of the mammary gland / MGI
  • increased diameter of tibia / MGI
  • abnormal osteoclast differentiation / MGI
  • increased circulating tumor necrosis factor level / MGI
  • decreased circulating tumor necrosis factor level / MGI
  • increased tumor necrosis factor secretion / MGI
  • abnormal interleukin secretion / MGI
  • increased circulating interferon-gamma level / MGI
  • increased circulating interleukin-2 level / MGI
  • increased interleukin-1 beta secretion / MGI
  • increased interleukin-10 secretion / MGI
  • increased interleukin-6 secretion / MGI
  • impaired neutrophil recruitment / MGI
  • abnormal chemokine secretion / MGI
  • decreased transforming growth factor level / MGI
  • decreased sensitivity to induced cell death / MGI
  • abnormal epidermal lamellar body morphology / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • abnormal circulating chemokine level / MGI
  • abnormal circulating cytokine level / MGI
  • decreased activation-induced cell death of T cells / MGI
  • increased mitochondria size / MGI
  • abnormal mitochondrial crista morphology / MGI
  • decreased fibroblast proliferation / MGI
  • impaired leukocyte tethering or rolling / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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