129(B6)-Serpine1^tm1Mlg Apoe^tm1Bres/CljH[cc]

Status	Available to order
EMMA ID	EM:02066
International strain name	129(B6)-Serpine1^tm1Mlg Apoe^tm1Bres/CljH[cc]
Alternative name	ApoE/PAI-1
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Apoe^tm1Bres, Serpine1^tm1Mlg
Gene/Transgene symbol	Apoe, Serpine1

Information from provider

Provider	Christopher Jackson
Provider affiliation	University of Bristol
Genetic information	Targeted null mutation of the apolipoprotein E and Serpine1 (formerly plasminogen activator inhibitor-1, PAI-1) genes.
Phenotypic information	Shortened life span.
Breeding history	Mice were congenic on a 129 background.
References	Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598 Biological effects of disruption of the tissue-type plasminogen activator, urokinase-type plasminogen activator, and plasminogen activator inhibitor-1 genes in mice.;Carmeliet P, Bouché A, De Clercq C, Janssen S, Pollefeyt S, Wyns S, Mulligan R C, Collen D, ;1995;Annals of the New York Academy of Sciences;748;367-81; discussion 381-2; 7695179

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archiving	homozygous 129
Breeding at archiving centre	Males were archived at the time of arrival. No breeding was performed at the archiving centre. Males were understood to be homozygous congenic on a 129 background.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Congenital plasminogen activator inhibitor type 1 deficiency / Orphanet_465
Sea-blue histiocytosis / Orphanet_158029
Lipoprotein glomerulopathy / Orphanet_329481

IMPC phenotypes (gene matching)

increased circulating triglyceride level / IMPC
increased circulating cholesterol level / IMPC
abnormal sternum morphology / IMPC
increased circulating alkaline phosphatase level / IMPC
increased circulating LDL cholesterol level / IMPC
decreased circulating glucose level / IMPC
enlarged lymph nodes / IMPC
increased circulating bilirubin level / IMPC
abnormal tooth morphology / IMPC
decreased circulating serum albumin level / IMPC
abnormal glucose homeostasis / IMPC

MGI phenotypes (allele matching)

abnormal digestive system physiology / MGI
increased circulating cholesterol level / MGI
abnormal circulating cholesterol level / MGI
xanthoma / MGI
atherosclerotic lesions / MGI
abnormal circulating LDL cholesterol level / MGI
abnormal cerebral cortex morphology / MGI
abnormal hippocampus morphology / MGI
abnormal neuron morphology / MGI
increased circulating VLDL cholesterol level / MGI
increased triglyceride level / MGI
increased susceptibility to atherosclerosis / MGI
decreased circulating HDL cholesterol level / MGI
increased circulating triglyceride level / MGI
heart inflammation / MGI
increased susceptibility to bacterial infection / MGI
cardiac fibrosis / MGI
liver fibrosis / MGI
liver/biliary system phenotype / MGI
abnormal enzyme/coenzyme activity / MGI
increased angiogenesis / MGI
increased sensitivity to induced morbidity/mortality / MGI
decreased susceptibility to endotoxin shock / MGI
decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
increased granulocyte number / MGI
abnormal lung morphology / MGI
abnormal body weight / MGI
decreased body weight / MGI
weight loss / MGI
neoplasm / MGI
abnormal blood circulation / MGI
respiratory system inflammation / MGI
abnormal acute inflammation / MGI
enhanced wound healing / MGI
glomerulonephritis / MGI
increased urine protein level / MGI
increased acute inflammation / MGI
increased oxygen consumption / MGI
decreased triglyceride level / MGI
immune system phenotype / MGI
hematopoietic system phenotype / MGI
abnormal energy expenditure / MGI
increased body temperature / MGI
decreased angiogenesis / MGI
abnormal epididymal fat pad morphology / MGI
decreased circulating interleukin-6 level / MGI
abnormal interleukin level / MGI
decreased subcutaneous adipose tissue amount / MGI
decreased liver triglyceride level / MGI
glomerular crescent / MGI
hyperglycemia / MGI
abnormal kidney morphology / MGI
decreased circulating cholesterol level / MGI
abnormal renal glomerulus morphology / MGI
homeostasis/metabolism phenotype / MGI
increased blood urea nitrogen level / MGI

MGI phenotypes (gene matching)

abnormal cochlea morphology / MGI
organ of Corti degeneration / MGI
abnormal stria vascularis morphology / MGI
increased bone mineral density / MGI
abnormal circulating cholesterol level / MGI
abnormal circulating LDL cholesterol level / MGI
increased circulating LDL cholesterol level / MGI
decreased circulating LDL cholesterol level / MGI
decreased circulating HDL cholesterol level / MGI
abnormal triglyceride level / MGI
decreased hematocrit / MGI
abnormal blood flow velocity / MGI
abnormal blood vessel physiology / MGI
alopecia / MGI
abnormal liver physiology / MGI
abnormal adrenal gland morphology / MGI
abnormal immune system morphology / MGI
abnormal cerebral cortex morphology / MGI
abnormal hippocampus morphology / MGI
skin lesions / MGI
decreased body length / MGI
decreased body weight / MGI
corneal opacity / MGI
retinal degeneration / MGI
increased anxiety-related response / MGI
abnormal nursing / MGI
abnormal locomotor behavior / MGI
hyperactivity / MGI
abnormal response to new environment / MGI
decreased exploration in new environment / MGI
abnormal spatial learning / MGI
increased startle reflex / MGI
decreased startle reflex / MGI
abnormal kindling response / MGI
abnormal skeleton physiology / MGI
abnormal lipid level / MGI
hyperlipidemia / MGI
increased circulating triglyceride level / MGI
increased circulating HDL cholesterol level / MGI
cardiac hypertrophy / MGI
abnormal digestive system physiology / MGI
abnormal postnatal growth / MGI
hypersecretion of corticosterone / MGI
increased circulating corticosterone level / MGI
abnormal immune system physiology / MGI
lung inflammation / MGI
vascular inflammation / MGI
abnormal lung volume / MGI
deafness / MGI
abnormal glucose homeostasis / MGI
premature death / MGI
abnormal lipid homeostasis / MGI
abnormal brain morphology / MGI
abnormal gland physiology / MGI
abnormal pulmonary alveolus morphology / MGI
abnormal dendritic cell physiology / MGI
abnormal cell-mediated immunity / MGI
increased immunoglobulin level / MGI
increased IgM level / MGI
decreased circulating triglyceride level / MGI
abnormal sciatic nerve morphology / MGI
abnormal immune serum protein physiology / MGI
abnormal thermal nociception / MGI
decreased vertical activity / MGI
increased thigmotaxis / MGI
increased heart weight / MGI
cochlear ganglion degeneration / MGI
abnormal neuron morphology / MGI
no phenotypic analysis / MGI
altered response to CNS ischemic injury / MGI
abnormal tectorial membrane morphology / MGI
impaired muscle relaxation / MGI
increased cholesterol efflux / MGI
amyloid beta deposits / MGI
hypopituitarism / MGI
increased cardiac output / MGI
nervous system phenotype / MGI
oxidative stress / MGI
xanthoma / MGI
increased autoantibody level / MGI
abnormal retinal inner nuclear layer morphology / MGI
abnormal bone structure / MGI
abnormal myelin sheath morphology / MGI
abnormal circulating lipid level / MGI
abnormal plasma membrane morphology / MGI
increased circulating VLDL triglyceride level / MGI
decreased circulating VLDL triglyceride level / MGI
increased circulating phospholipid level / MGI
arteriosclerosis / MGI
increased compact bone thickness / MGI
abnormal basilar membrane morphology / MGI
cochlear inner hair cell degeneration / MGI
cochlear outer hair cell degeneration / MGI
abnormal spiral modiolar artery morphology / MGI
spiral modiolar artery stenosis / MGI
increased anti-double stranded DNA antibody level / MGI
abnormal synaptic vesicle morphology / MGI
abnormal phospholipid level / MGI
increased anti-nuclear antigen antibody level / MGI
increased susceptibility to systemic lupus erythematosus / MGI
decreased systemic vascular resistance / MGI
increased spleen weight / MGI
abnormal osteoblast physiology / MGI
increased B cell number / MGI
abnormal response to infection / MGI
increased susceptibility to parasitic infection / MGI
increased circulating VLDL cholesterol level / MGI
decreased circulating VLDL cholesterol level / MGI
abnormal blood-brain barrier function / MGI
increased circulating cholesterol level / MGI
decreased circulating cholesterol level / MGI
abnormal retinal pigment epithelium morphology / MGI
abnormal Bruch membrane morphology / MGI
abnormal cholesterol homeostasis / MGI
impaired glucose tolerance / MGI
increased triglyceride level / MGI
abnormal renal glomerulus morphology / MGI
atherosclerotic lesions / MGI
increased susceptibility to atherosclerosis / MGI
altered susceptibility to atherosclerosis / MGI
decreased susceptibility to atherosclerosis / MGI
liver/biliary system phenotype / MGI
homeostasis/metabolism phenotype / MGI
behavior/neurological phenotype / MGI
vascular stenosis / MGI
abnormal circulating protein level / MGI
increased susceptibility to weight gain / MGI
retinal pigment epithelium atrophy / MGI
abnormal eye electrophysiology / MGI
decreased circulating glucose level / MGI
abnormal enzyme/coenzyme activity / MGI
decreased vasodilation / MGI
decreased susceptibility to type IV hypersensitivity reaction / MGI
decreased circulating leptin level / MGI
decreased cerebral infarction size / MGI
abnormal epididymal fat pad morphology / MGI
abnormal T cell number / MGI
abnormal CD4-positive, alpha beta T cell number / MGI
increased CD4-positive, alpha beta T cell number / MGI
increased T-helper 2 cell number / MGI
abnormal dendrite morphology / MGI
decreased follicular B cell number / MGI
increased marginal zone B cell number / MGI
decreased marginal zone B cell number / MGI
abnormal B cell activation / MGI
abnormal adrenal cortex morphology / MGI
abnormal adrenal medulla morphology / MGI
abnormal spatial reference memory / MGI
abnormal spatial working memory / MGI
thin retinal inner nuclear layer / MGI
thin retinal outer nuclear layer / MGI
impaired olfaction / MGI
increased tumor necrosis factor secretion / MGI
decreased tumor necrosis factor secretion / MGI
decreased interferon-gamma secretion / MGI
increased interleukin-6 secretion / MGI
decreased interleukin-6 secretion / MGI
retinal neovascularization / MGI
abnormal astrocyte physiology / MGI
abnormal fat cell morphology / MGI
decreased epididymal fat pad weight / MGI
abnormal synapse morphology / MGI
increased prostaglandin level / MGI
abnormal aorta wall morphology / MGI
decreased brain cholesterol level / MGI
kidney microaneurysm / MGI
increased bone trabecula number / MGI
increased lung compliance / MGI
increased airway resistance / MGI
abnormal lung hysteresivity / MGI
abnormal kidney arterial blood vessel morphology / MGI
expanded mesangial matrix / MGI
mesangiolysis / MGI
glomerular capillary thrombosis / MGI
dilated glomerular capillary / MGI
renal glomerulus lipidosis / MGI
increased food intake / MGI
increased fluid intake / MGI
increased cardiac stroke volume / MGI
increased or absent threshold for auditory brainstem response / MGI
decreased circulating homocysteine level / MGI
decreased brown adipose tissue mass / MGI
increased granulocyte number / MGI
abnormal lung morphology / MGI
abnormal body weight / MGI
decreased body weight / MGI
weight loss / MGI
hyperglycemia / MGI
heart inflammation / MGI
neoplasm / MGI
abnormal blood circulation / MGI
abnormal kidney morphology / MGI
respiratory system inflammation / MGI
increased susceptibility to bacterial infection / MGI
abnormal acute inflammation / MGI
enhanced wound healing / MGI
glomerulonephritis / MGI
increased urine protein level / MGI
cardiac fibrosis / MGI
liver fibrosis / MGI
increased acute inflammation / MGI
decreased circulating cholesterol level / MGI
increased oxygen consumption / MGI
decreased triglyceride level / MGI
abnormal renal glomerulus morphology / MGI
liver/biliary system phenotype / MGI
homeostasis/metabolism phenotype / MGI
immune system phenotype / MGI
hematopoietic system phenotype / MGI
abnormal energy expenditure / MGI
increased body temperature / MGI
increased blood urea nitrogen level / MGI
abnormal enzyme/coenzyme activity / MGI
increased angiogenesis / MGI
decreased angiogenesis / MGI
abnormal epididymal fat pad morphology / MGI
decreased circulating interleukin-6 level / MGI
decreased susceptibility to endotoxin shock / MGI
abnormal interleukin level / MGI
decreased subcutaneous adipose tissue amount / MGI
decreased liver triglyceride level / MGI
increased sensitivity to induced morbidity/mortality / MGI
decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
glomerular crescent / MGI

Literature references

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598
Biological effects of disruption of the tissue-type plasminogen activator, urokinase-type plasminogen activator, and plasminogen activator inhibitor-1 genes in mice.;Carmeliet P, Bouché A, De Clercq C, Janssen S, Pollefeyt S, Wyns S, Mulligan R C, Collen D, ;1995;Annals of the New York Academy of Sciences;748;367-81; discussion 381-2; 7695179

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

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129(B6)-Serpine1tm1Mlg Apoetm1Bres/CljH[cc]