STOCK Ighmtm1.1Aak/Orl

Status

Available to order

EMMA IDEM:02108
International strain nameSTOCK Ighmtm1.1Aak/Orl
Alternative namepAp-mu
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolIghmtm1.1Aak
Gene/Transgene symbolIghm

Information from provider

ProviderAhmed Amine Khamlichi
Provider affiliationCNRS UMR 6101
Genetic informationTargeting construct is derived from 129 DNA. The insertion brings polyadenylation and pause sites upstream of Smu region. All elements have been left intact.
Phenotypic informationAlteration of germline transcription elongation. A general defect in class switching to all isotypes.
Breeding historyBred with C57BL/6 for several generations.
References
  • Sense transcription through the S region is essential for immunoglobulin class switch recombination.;Haddad Dania, Oruc Zéliha, Puget Nadine, Laviolette-Malirat Nathalie, Philippe Magali, Carrion Claire, Le Bert Marc, Khamlichi Ahmed Amine, ;2011;The EMBO journal;30;1608-20; 21378751

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal class switch recombination / MGI
  • decreased B cell number / MGI
  • immune system phenotype / MGI
  • increased pro-B cell number / MGI
  • decreased pre-B cell number / MGI
MGI phenotypes (gene matching)
  • decreased bone mineral density / MGI
  • abnormal trabecular bone morphology / MGI
  • decreased compact bone thickness / MGI
  • abnormal intestinal epithelium morphology / MGI
  • abnormal spleen morphology / MGI
  • abnormal cardiovascular system physiology / MGI
  • abnormal immune system physiology / MGI
  • abnormal humoral immune response / MGI
  • arrested B cell differentiation / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • decreased IgA level / MGI
  • abnormal antigen presentation / MGI
  • kidney inflammation / MGI
  • abnormal lymphatic vessel morphology / MGI
  • abnormal respiratory system physiology / MGI
  • abnormal B cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • small lymph nodes / MGI
  • abnormal spleen white pulp morphology / MGI
  • abnormal spleen periarteriolar lymphoid sheath morphology / MGI
  • abnormal spleen germinal center morphology / MGI
  • abnormal spleen marginal zone morphology / MGI
  • abnormal spleen marginal sinus morphology / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal B cell physiology / MGI
  • decreased immunoglobulin level / MGI
  • abnormal complement pathway / MGI
  • impaired complement classical pathway / MGI
  • decreased IgE level / MGI
  • increased IgM level / MGI
  • increased IgA level / MGI
  • abnormal immune serum protein physiology / MGI
  • abnormal cytokine secretion / MGI
  • no phenotypic analysis / MGI
  • increased susceptibility to induced arthritis / MGI
  • increased autoantibody level / MGI
  • abnormal compact bone morphology / MGI
  • insulitis / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased susceptibility to autoimmune diabetes / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • abnormal class switch recombination / MGI
  • decreased spleen weight / MGI
  • increased B-1 B cell number / MGI
  • decreased B-1 B cell number / MGI
  • increased osteoclast cell number / MGI
  • increased B cell number / MGI
  • decreased B cell number / MGI
  • abnormal immature B cell morphology / MGI
  • abnormal response to infection / MGI
  • increased susceptibility to parasitic infection / MGI
  • decreased B cell proliferation / MGI
  • abnormal T cell proliferation / MGI
  • decreased T cell proliferation / MGI
  • increased B cell proliferation / MGI
  • decreased susceptibility to injury / MGI
  • immune system phenotype / MGI
  • respiratory system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • decreased susceptibility to type IV hypersensitivity reaction / MGI
  • abnormal T cell number / MGI
  • absent B cells / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • increased plasma cell number / MGI
  • abnormal plasma cell differentiation / MGI
  • decreased dendritic cell number / MGI
  • decreased Peyer's patch number / MGI
  • small Peyer's patches / MGI
  • abnormal B-1a B cell morphology / MGI
  • abnormal mature B cell morphology / MGI
  • decreased follicular B cell number / MGI
  • increased marginal zone B cell number / MGI
  • decreased marginal zone B cell number / MGI
  • increased pro-B cell number / MGI
  • decreased transitional stage B cell number / MGI
  • abnormal follicular dendritic cell antigen presentation / MGI
  • absent follicular dendritic cells / MGI
  • decreased pre-B cell number / MGI
  • decreased mature B cell number / MGI
  • absent mature B cells / MGI
  • absent immature B cells / MGI
  • decreased immature B cell number / MGI
  • abnormal B cell activation / MGI
  • abnormal spleen marginal zone macrophage morphology / MGI
  • abnormal metallophilic macrophage morphology / MGI
  • abnormal CD8 positive, alpha-beta intraepithelial T cell morphology / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • decreased IgG2b level / MGI
  • decreased IgG3 level / MGI
  • increased IgG2a level / MGI
  • increased IgG3 level / MGI
  • abnormal splenic cell ratio / MGI
  • decreased trabecular bone thickness / MGI
  • decreased compact bone volume / MGI

Literature references

  • Sense transcription through the S region is essential for immunoglobulin class switch recombination.;Haddad Dania, Oruc Zéliha, Puget Nadine, Laviolette-Malirat Nathalie, Philippe Magali, Carrion Claire, Le Bert Marc, Khamlichi Ahmed Amine, ;2011;The EMBO journal;30;1608-20; 21378751

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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