STOCK Ighmtm1.1Aak/Orl
Status | Available to order |
EMMA ID | EM:02108 |
International strain name | STOCK Ighmtm1.1Aak/Orl |
Alternative name | pAp-mu |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Ighmtm1.1Aak |
Gene/Transgene symbol | Ighm |
Information from provider
Provider | Ahmed Amine Khamlichi |
Provider affiliation | CNRS UMR 6101 |
Genetic information | Targeting construct is derived from 129 DNA. The insertion brings polyadenylation and pause sites upstream of Smu region. All elements have been left intact. |
Phenotypic information | Alteration of germline transcription elongation. A general defect in class switching to all isotypes. |
Breeding history | Bred with C57BL/6 for several generations. |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal agammaglobulinemia / Orphanet_33110
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- abnormal trabecular bone morphology / MGI
- decreased compact bone thickness / MGI
- abnormal intestinal epithelium morphology / MGI
- abnormal spleen morphology / MGI
- abnormal cardiovascular system physiology / MGI
- abnormal immune system physiology / MGI
- abnormal humoral immune response / MGI
- arrested B cell differentiation / MGI
- decreased IgG level / MGI
- decreased IgM level / MGI
- decreased IgA level / MGI
- abnormal antigen presentation / MGI
- kidney inflammation / MGI
- abnormal lymphatic vessel morphology / MGI
- abnormal respiratory system physiology / MGI
- abnormal B cell differentiation / MGI
- no abnormal phenotype detected / MGI
- small lymph nodes / MGI
- abnormal spleen white pulp morphology / MGI
- abnormal spleen periarteriolar lymphoid sheath morphology / MGI
- abnormal spleen germinal center morphology / MGI
- abnormal spleen marginal zone morphology / MGI
- abnormal spleen marginal sinus morphology / MGI
- increased susceptibility to viral infection / MGI
- abnormal B cell physiology / MGI
- decreased immunoglobulin level / MGI
- abnormal complement pathway / MGI
- impaired complement classical pathway / MGI
- decreased IgE level / MGI
- increased IgM level / MGI
- increased IgA level / MGI
- abnormal immune serum protein physiology / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- increased susceptibility to induced arthritis / MGI
- increased autoantibody level / MGI
- abnormal compact bone morphology / MGI
- insulitis / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased susceptibility to autoimmune diabetes / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- abnormal class switch recombination / MGI
- decreased spleen weight / MGI
- increased B-1 B cell number / MGI
- decreased B-1 B cell number / MGI
- increased osteoclast cell number / MGI
- increased B cell number / MGI
- decreased B cell number / MGI
- abnormal immature B cell morphology / MGI
- abnormal response to infection / MGI
- increased susceptibility to parasitic infection / MGI
- decreased B cell proliferation / MGI
- abnormal T cell proliferation / MGI
- decreased T cell proliferation / MGI
- increased B cell proliferation / MGI
- decreased susceptibility to injury / MGI
- immune system phenotype / MGI
- respiratory system phenotype / MGI
- abnormal CD4-positive, alpha-beta T cell physiology / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- abnormal T cell number / MGI
- absent B cells / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- increased plasma cell number / MGI
- abnormal plasma cell differentiation / MGI
- decreased dendritic cell number / MGI
- decreased Peyer's patch number / MGI
- small Peyer's patches / MGI
- abnormal B-1a B cell morphology / MGI
- abnormal mature B cell morphology / MGI
- decreased follicular B cell number / MGI
- increased marginal zone B cell number / MGI
- decreased marginal zone B cell number / MGI
- increased pro-B cell number / MGI
- decreased transitional stage B cell number / MGI
- abnormal follicular dendritic cell antigen presentation / MGI
- absent follicular dendritic cells / MGI
- decreased pre-B cell number / MGI
- decreased mature B cell number / MGI
- absent mature B cells / MGI
- absent immature B cells / MGI
- decreased immature B cell number / MGI
- abnormal B cell activation / MGI
- abnormal spleen marginal zone macrophage morphology / MGI
- abnormal metallophilic macrophage morphology / MGI
- abnormal CD8 positive, alpha-beta intraepithelial T cell morphology / MGI
- abnormal spleen B cell follicle morphology / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased IgG2b level / MGI
- decreased IgG3 level / MGI
- increased IgG2a level / MGI
- increased IgG3 level / MGI
- abnormal splenic cell ratio / MGI
- decreased trabecular bone thickness / MGI
- decreased compact bone volume / MGI
Literature references
- Sense transcription through the S region is essential for immunoglobulin class switch recombination.;Haddad Dania, Oruc Zéliha, Puget Nadine, Laviolette-Malirat Nathalie, Philippe Magali, Carrion Claire, Le Bert Marc, Khamlichi Ahmed Amine, ;2011;The EMBO journal;30;1608-20; 21378751
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