MGI phenotypes (allele matching)
- immune system phenotype / MGI
STOCK Igh-8tm2.1Aak/Orl
| Status | Available to order |
| EMMA ID | EM:02109 |
| International strain name | STOCK Igh-8tm2.1Aak/Orl |
| Alternative name | pAp-gamma3 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Igh-8tm2.1Aak |
| Gene/Transgene symbol | Igh-8 |
Information from provider
| Provider | Ahmed Amine Khamlichi |
| Provider affiliation | CNRS UMR 6101 |
| Genetic information | Targeting construct is derived from 129 DNA. The insertion brings polyadenylation and pause sites upstream of Sgamma3 region. All elements have been left intact. |
| Phenotypic information | Inhibition of germline transcription elongation. A specific defect in class switching to IgG3. |
| Breeding history | Bred with C57BL/6 for several generations. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Literature references
- Sense transcription through the S region is essential for immunoglobulin class switch recombination.;Haddad Dania, Oruc Zéliha, Puget Nadine, Laviolette-Malirat Nathalie, Philippe Magali, Carrion Claire, Le Bert Marc, Khamlichi Ahmed Amine, ;2011;The EMBO journal;30;1608-20; 21378751