129-Ightm3.1Cog/Orl

Status

Available to order

EMMA IDEM:00212
International strain name129-Ightm3.1Cog/Orl
Alternative namedelta hs3b/hs4
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolIghtm3.1Cog
Gene/Transgene symbolIgh

Information from provider

ProviderMichel Cogne
Provider affiliationUMR CNRS 6101, Universite de Limoges
Genetic informationDeletion of the hs3b and hs4 transcriptional enhancers within the Igh locus, 3 prime-regulatory region.
Phenotypic informationImmunoglobulin IgG2b, IgG2a, IgG3, IgE and IgA class switching defects.
References
  • Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination.;Pinaud E, Khamlichi A A, Le Morvan C, Drouet M, Nalesso V, Le Bert M, Cogné M, ;2001;Immunity;15;187-99; 11520455

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased IgG level / MGI
  • decreased IgA level / MGI
  • decreased immunoglobulin level / MGI
  • decreased IgE level / MGI
  • abnormal class switch recombination / MGI
  • immune system phenotype / MGI
  • decreased IgG2a level / MGI
  • decreased IgG2b level / MGI
  • decreased IgG3 level / MGI
MGI phenotypes (gene matching)
  • abnormal bone marrow cell number / MGI
  • absent pre-B cells / MGI
  • abnormal heart morphology / MGI
  • decreased bone marrow cell number / MGI
  • abnormal liver morphology / MGI
  • abnormal salivary gland morphology / MGI
  • lymphoid hyperplasia / MGI
  • abnormal spleen morphology / MGI
  • enlarged spleen / MGI
  • small spleen / MGI
  • spleen hypoplasia / MGI
  • enlarged lymph nodes / MGI
  • abnormal thymus morphology / MGI
  • enlarged thymus / MGI
  • abnormal lung morphology / MGI
  • abnormal immune system physiology / MGI
  • abnormal humoral immune response / MGI
  • arrested B cell differentiation / MGI
  • decreased IgG level / MGI
  • decreased IgM level / MGI
  • decreased IgA level / MGI
  • thymus hypoplasia / MGI
  • reduced male fertility / MGI
  • increased tumor incidence / MGI
  • increased B cell derived lymphoma incidence / MGI
  • increased T cell derived lymphoma incidence / MGI
  • increased leukemia incidence / MGI
  • premature death / MGI
  • abnormal kidney morphology / MGI
  • abnormal B cell differentiation / MGI
  • abnormal T cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal lymph node morphology / MGI
  • abnormal gut-associated lymphoid tissue morphology / MGI
  • abnormal Peyer's patch germinal center morphology / MGI
  • abnormal B cell number / MGI
  • abnormal B cell physiology / MGI
  • decreased immunoglobulin level / MGI
  • abnormal immunoglobulin level / MGI
  • decreased IgD level / MGI
  • decreased IgE level / MGI
  • increased IgG level / MGI
  • increased IgM level / MGI
  • increased IgA level / MGI
  • increased IgE level / MGI
  • absent Peyer's patches / MGI
  • no phenotypic analysis / MGI
  • abnormal cell cycle / MGI
  • increased pre-B cell number / MGI
  • increased early pro-B cell number / MGI
  • increased late pro-B cell number / MGI
  • abnormal tumor morphology / MGI
  • increased autoantibody level / MGI
  • increased anti-nuclear antigen antibody level / MGI
  • abnormal somatic hypermutation frequency / MGI
  • abnormal class switch recombination / MGI
  • abnormal B cell morphology / MGI
  • abnormal B-1 B cell morphology / MGI
  • increased B cell number / MGI
  • decreased B cell number / MGI
  • abnormal late pro-B cell / MGI
  • abnormal immature B cell morphology / MGI
  • decreased double-negative T cell number / MGI
  • decreased double-positive T cell number / MGI
  • abnormal B cell proliferation / MGI
  • increased B cell proliferation / MGI
  • cellular phenotype / MGI
  • immune system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • absent B cells / MGI
  • absent plasma cells / MGI
  • lymph node hyperplasia / MGI
  • abnormal B-1a B cell morphology / MGI
  • decreased B-1a cell number / MGI
  • decreased B-1b cell number / MGI
  • abnormal mature B cell morphology / MGI
  • decreased follicular B cell number / MGI
  • abnormal marginal zone B cell morphology / MGI
  • increased marginal zone B cell number / MGI
  • decreased marginal zone B cell number / MGI
  • increased pro-B cell number / MGI
  • decreased transitional stage B cell number / MGI
  • abnormal marginal zone B cell physiology / MGI
  • absent B-1 B cells / MGI
  • absent B-1a cells / MGI
  • absent B-1b cells / MGI
  • decreased pre-B cell number / MGI
  • decreased mature B cell number / MGI
  • absent mature B cells / MGI
  • decreased immature B cell number / MGI
  • abnormal B cell activation / MGI
  • abnormal spleen B cell follicle morphology / MGI
  • absent spleen germinal center / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • decreased IgG2b level / MGI
  • decreased IgG3 level / MGI
  • increased IgG1 level / MGI
  • increased IgG3 level / MGI
  • abnormal lymph node germinal center morphology / MGI
  • abnormal immunoglobulin V(D)J recombination / MGI
  • abnormal immunoglobulin heavy chain V(D)J recombination / MGI
  • abnormal immunoglobulin light chain V-J recombination / MGI
  • increased B cell apoptosis / MGI
  • decreased transitional stage T2 B cell number / MGI
  • increased plasmacytoma incidence / MGI
  • increased chronic lymphocytic leukemia incidence / MGI
  • increased lymphoma incidence / MGI

Literature references

  • Localization of the 3' IgH locus elements that effect long-distance regulation of class switch recombination.;Pinaud E, Khamlichi A A, Le Morvan C, Drouet M, Nalesso V, Le Bert M, Cogné M, ;2001;Immunity;15;187-99; 11520455

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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