IMPC phenotypes (gene matching)
C57BL/6Apb-Lcp2twm/ApbH
| Status | Available to order |
| EMMA ID | EM:02184 |
| International strain name | C57BL/6Apb-Lcp2twm/ApbH |
| Alternative name | T-wimp C57BL/6Apb-Lcp2 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Lcp2twm |
| Gene/Transgene symbol | Lcp2 |
Information from provider
| Provider | Chris Goodnow |
| Provider affiliation | The Australian National University |
| Genetic information | This strain was identified during systematically screening of the mouse genome for autoimmune regulators. The phenotype of this strain is less severe than strains carrying gene knock-out which is embryonic lethal. This strain may assist in the elucidation of the mechanisms of autoimmune disease and T cell development. |
| Phenotypic information | The mutant line possesses few naive CD4+ and CD8+ T cells, autoimmunity, 5-fold decrease in double-positive (DP) T cells and significantly fewer CD4+ and CD8+ single-positive (SP) cells, partial block in T cell development at the pre TCR checkpoint, very low expression of CD5 on DP thymocytes, defect in TCR signaling, mutation intrinsic to thymocytes, reduced expression of Slp76, defects in positive selection and reduced negative thymocyte selection, hypergammaglobulinemia and hyper-IgE. |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (allele matching)
- decreased thymocyte number / MGI
- arrested T cell differentiation / MGI
- autoimmune response / MGI
- abnormal double-positive T cell morphology / MGI
- abnormal T cell physiology / MGI
- increased IgG level / MGI
- increased IgE level / MGI
- abnormal negative T cell selection / MGI
- abnormal positive T cell selection / MGI
- decreased T cell number / MGI
MGI phenotypes (gene matching)
- small thymus / MGI
- decreased thymocyte number / MGI
- thymus hypoplasia / MGI
- arrested T cell differentiation / MGI
- abnormal T cell activation / MGI
- autoimmune response / MGI
- abnormal T cell differentiation / MGI
- abnormal double-negative T cell morphology / MGI
- abnormal double-positive T cell morphology / MGI
- abnormal effector T cell morphology / MGI
- abnormal T cell physiology / MGI
- increased IgG level / MGI
- increased IgE level / MGI
- abnormal thymocyte activation / MGI
- abnormal T cell subpopulation ratio / MGI
- abnormal negative T cell selection / MGI
- abnormal positive T cell selection / MGI
- decreased T cell number / MGI
- impaired natural killer cell mediated cytotoxicity / MGI
- decreased double-negative T cell number / MGI
- increased double-negative T cell number / MGI
- decreased double-positive T cell number / MGI
- decreased T cell proliferation / MGI
- immune system phenotype / MGI
- abnormal platelet activation / MGI
- decreased NK T cell number / MGI
- increased NK cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased single-positive T cell number / MGI
- lymph node hypoplasia / MGI
- decreased interferon-gamma secretion / MGI
- decreased interleukin-2 secretion / MGI
- decreased platelet aggregation / MGI
- abnormal NK cell physiology / MGI
- perinatal lethality, incomplete penetrance / MGI