B6.129-Cnr1^tm1Zim Cnr2^tm1Zim/Ieg

Status	Available to order
EMMA ID	EM:02273
International strain name	B6.129-Cnr1^tm1Zim Cnr2^tm1Zim/Ieg
Alternative name	Cnr1 tm1zim/ Cnr2 tm2zim
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Cnr1^tm1Zim, Cnr2^tm1Zim
Gene/Transgene symbol	Cnr1, Cnr2

Information from provider

Provider	Andreas Zimmer
Provider affiliation	Institute of Molecular Psychiatry
Genetic information	See references: PubMed_ID 10318961 and PubMed_ID 10822068.
Phenotypic information	Allergic contact dermatitis.
References	Attenuation of allergic contact dermatitis through the endocannabinoid system.;Karsak Meliha, Gaffal Evelyn, Date Rahul, Wang-Eckhardt Lihua, Rehnelt Jennifer, Petrosino Stefania, Starowicz Katarzyna, Steuder Regina, Schlicker Eberhard, Cravatt Benjamin, Mechoulam Raphael, Buettner Reinhard, Werner Sabine, Di Marzo Vincenzo, Tüting Thomas, Zimmer Andreas, ;2007;Science (New York, N.Y.);316;1494-7; 17556587 Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.;Járai Z, Wagner J A, Varga K, Lake K D, Compton D R, Martin B R, Zimmer A M, Bonner T I, Buckley N E, Mezey E, Razdan R K, Zimmer A, Kunos G, ;1999;Proceedings of the National Academy of Sciences of the United States of America;96;14136-41; 10570211

Information from EMMA

Archiving centre	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archiving	homozygous C57BL/6N

Disease and phenotype information

IMPC phenotypes (gene matching)

preweaning lethality, incomplete penetrance / IMPC
enlarged spleen / IMPC
enlarged cecum / IMPC
hyperactivity / IMPC
abnormal skin morphology / IMPC
decreased thigmotaxis / IMPC
edema / IMPC
abnormal behavior / IMPC
abnormal spleen morphology / IMPC
abnormal kidney morphology / IMPC
preweaning lethality, complete penetrance / IMPC
small kidney / IMPC
abnormal cecum morphology / IMPC
increased bone mineral content / IMPC
abnormal skin morphology / IMPC

MGI phenotypes (allele matching)

hypoactivity / MGI
increased circulating corticosterone level / MGI
increased thermal nociceptive threshold / MGI
premature death / MGI
decreased vertical activity / MGI
catalepsy / MGI
hypoalgesia / MGI
maternal effect / MGI
increased follicle stimulating hormone level / MGI
increased circulating estradiol level / MGI
decreased circulating progesterone level / MGI
increased chemical nociceptive threshold / MGI
decreased survivor rate / MGI
impaired behavioral response to addictive substance / MGI
postnatal lethality, incomplete penetrance / MGI
early parturition / MGI
abnormal macrophage physiology / MGI
immune system phenotype / MGI
reproductive system phenotype / MGI

MGI phenotypes (gene matching)

increased bone mineral density / MGI
abnormal cerebral cortex morphology / MGI
decreased body weight / MGI
weight loss / MGI
increased aggression towards mice / MGI
increased anxiety-related response / MGI
hyperactivity / MGI
hypoactivity / MGI
increased exploration in new environment / MGI
decreased exploration in new environment / MGI
abnormal cued conditioning behavior / MGI
reduced long term depression / MGI
increased circulating corticosterone level / MGI
increased circulating adrenocorticotropin level / MGI
absent long term depression / MGI
increased thermal nociceptive threshold / MGI
increased chemically-elicited antinociception / MGI
decreased chemically-elicited antinociception / MGI
abnormal learning/memory/conditioning / MGI
premature death / MGI
no abnormal phenotype detected / MGI
abnormal social/conspecific interaction / MGI
abnormal sperm motility / MGI
decreased circulating insulin level / MGI
decreased vertical activity / MGI
abnormal active avoidance behavior / MGI
catalepsy / MGI
increased insulin sensitivity / MGI
increased susceptibility to pharmacologically induced seizures / MGI
abnormal excitatory postsynaptic potential / MGI
decreased synaptic depression / MGI
abnormal paired-pulse facilitation / MGI
abnormal inhibitory postsynaptic currents / MGI
enhanced long term potentiation / MGI
no phenotypic analysis / MGI
hypoalgesia / MGI
increased susceptibility to ischemic brain injury / MGI
abnormal depression-related behavior / MGI
abnormal response to novel object / MGI
nervous system phenotype / MGI
abnormal nervous system morphology / MGI
abnormal nervous system physiology / MGI
maternal effect / MGI
abnormal nervous system development / MGI
abnormal sweet taste sensitivity / MGI
abnormal neuron physiology / MGI
abnormal synaptic plasticity / MGI
abnormal neuronal precursor proliferation / MGI
increased follicle stimulating hormone level / MGI
increased circulating estradiol level / MGI
decreased circulating progesterone level / MGI
behavior/neurological phenotype / MGI
skeleton phenotype / MGI
abnormal food intake / MGI
decreased percent body fat/body weight / MGI
decreased susceptibility to diet-induced obesity / MGI
decreased circulating leptin level / MGI
increased cerebral infarction size / MGI
increased susceptibility to neuronal excitotoxicity / MGI
increased chemical nociceptive threshold / MGI
decreased survivor rate / MGI
increased physiological sensitivity to xenobiotic / MGI
abnormal axon fasciculation / MGI
impaired cued conditioning behavior / MGI
anhedonia / MGI
impaired conditioned place preference behavior / MGI
impaired behavioral response to xenobiotic / MGI
impaired behavioral response to addictive substance / MGI
impaired behavioral response to morphine / MGI
increased sensitivity to induced morbidity/mortality / MGI
increased sensitivity to xenobiotic induced morbidity/mortality / MGI
increased behavioral withdrawal response / MGI
decreased total body fat amount / MGI
abnormal bone mineral density / MGI
postnatal lethality, incomplete penetrance / MGI
early parturition / MGI
alopecia / MGI
abnormal macrophage physiology / MGI
immune system phenotype / MGI
reproductive system phenotype / MGI

Literature references

Attenuation of allergic contact dermatitis through the endocannabinoid system.;Karsak Meliha, Gaffal Evelyn, Date Rahul, Wang-Eckhardt Lihua, Rehnelt Jennifer, Petrosino Stefania, Starowicz Katarzyna, Steuder Regina, Schlicker Eberhard, Cravatt Benjamin, Mechoulam Raphael, Buettner Reinhard, Werner Sabine, Di Marzo Vincenzo, Tüting Thomas, Zimmer Andreas, ;2007;Science (New York, N.Y.);316;1494-7; 17556587
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.;Járai Z, Wagner J A, Varga K, Lake K D, Compton D R, Martin B R, Zimmer A M, Bonner T I, Buckley N E, Mezey E, Razdan R K, Zimmer A, Kunos G, ;1999;Proceedings of the National Academy of Sciences of the United States of America;96;14136-41; 10570211

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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B6.129-Cnr1tm1Zim Cnr2tm1Zim/Ieg