IMPC phenotypes (gene matching)
129-Vimtm1Cba/Orl
| Status | Available to order |
| EMMA ID | EM:02411 |
| International strain name | 129-Vimtm1Cba/Orl |
| Alternative name | Vim1/Vim1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Vimtm1Cba |
| Gene/Transgene symbol | Vim |
Information from provider
| Provider | Emma Colucci-Guyon |
| Provider affiliation | Institut Pasteur |
| Genetic information | Exon 1 of the vimentin gene is interrupted with a LacZ expression cassette, that is in frame with the first 59 codons of the vimentin gene, followed by a TK-neo resistance cassette. This results in a null mutation of the vimentin locus and in a knock-in of the LacZ gene, which allows following the expression pattern of the vimentin gene via detection of the beta-galactosidase activity. The TKneo cassette is kept in the mutated allele. |
| Phenotypic information | Mice devoid of vimentin develop and reproduce without any obvious defects. |
| References |
|
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous 129S2/SvPas, homozygous 129S2/SvPas |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Pulverulent cataract / Orphanet_98984
MGI phenotypes (allele matching)
- abnormal vasoconstriction / MGI
- abnormal cell morphology / MGI
- abnormal cerebellum morphology / MGI
- abnormal cerebellar Purkinje cell layer / MGI
- Purkinje cell degeneration / MGI
- abnormal Purkinje cell morphology / MGI
- decreased Purkinje cell number / MGI
- increased anxiety-related response / MGI
- abnormal locomotor behavior / MGI
- hyperactivity / MGI
- impaired coordination / MGI
- impaired balance / MGI
- abnormal vasodilation / MGI
- abnormal astrocyte morphology / MGI
- abnormal motor learning / MGI
- abnormal cell migration / MGI
- nervous system phenotype / MGI
- decreased mean systemic arterial blood pressure / MGI
- embryo phenotype / MGI
- cardiovascular system phenotype / MGI
- respiratory system phenotype / MGI
- reproductive system phenotype / MGI
- increased circulating creatinine level / MGI
- abnormal cell physiology / MGI
- abnormal Purkinje cell dendrite morphology / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal blood vessel morphology / MGI
- abnormal leukocyte migration / MGI
- abnormal leukocyte tethering or rolling / MGI
- abnormal leukocyte adhesion / MGI
- homeostasis/metabolism phenotype / MGI
- cellular phenotype / MGI
- immune system phenotype / MGI
- abnormal cellular extravasation / MGI
MGI phenotypes (gene matching)
- abnormal vasoconstriction / MGI
- abnormal angiogenesis / MGI
- abnormal cell morphology / MGI
- abnormal cerebellum morphology / MGI
- abnormal cerebellar Purkinje cell layer / MGI
- Purkinje cell degeneration / MGI
- abnormal Purkinje cell morphology / MGI
- decreased Purkinje cell number / MGI
- increased anxiety-related response / MGI
- abnormal locomotor behavior / MGI
- hyperactivity / MGI
- impaired coordination / MGI
- impaired balance / MGI
- abnormal vasodilation / MGI
- abnormal blood vessel morphology / MGI
- abnormal astrocyte morphology / MGI
- abnormal motor learning / MGI
- abnormal cell migration / MGI
- abnormal leukocyte migration / MGI
- abnormal leukocyte tethering or rolling / MGI
- abnormal leukocyte adhesion / MGI
- nervous system phenotype / MGI
- decreased mean systemic arterial blood pressure / MGI
- homeostasis/metabolism phenotype / MGI
- embryo phenotype / MGI
- cellular phenotype / MGI
- cardiovascular system phenotype / MGI
- immune system phenotype / MGI
- respiratory system phenotype / MGI
- reproductive system phenotype / MGI
- increased circulating creatinine level / MGI
- abnormal cell physiology / MGI
- abnormal Purkinje cell dendrite morphology / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal cellular extravasation / MGI
Literature references
- Mice lacking vimentin develop and reproduce without an obvious phenotype.;Colucci-Guyon E, Portier M M, Dunia I, Paulin D, Pournin S, Babinet C, ;1994;Cell;79;679-94; 7954832