MGI phenotypes (allele matching)
B6.129P2-Prnp/Prndtm1Aag/Cnrm
| Status | Available to order |
| EMMA ID | EM:02432 |
| International strain name | B6.129P2-Prnp/Prndtm1Aag/Cnrm |
| Alternative name | C57Bl/6J-Prnd/PrnP (PrP-Dpl) double knockout mouse |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Prnp/Prndtm1Aag |
| Gene/Transgene symbol | Prnd |
Information from provider
| Provider | Adriano Aguzzi |
| Provider affiliation | Univ.Hosp.Zurich/Inst.Neuropathology |
| Additional owner | Dr. Andrew Steele, Whitehead Institute for Biomedical Research, Cambridge MA, USA |
| Genetic information | Large deletion of Prnp and Prnd genes, termed Prn locus deletion. |
| Phenotypic information | Male mice are infertile. |
| Breeding history | Backcrossed to C57BL/6J for 7 generations. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
- impaired fertilization / MGI
- male infertility / MGI
- abnormal spermiogenesis / MGI
- asthenozoospermia / MGI
- oligozoospermia / MGI
- nervous system phenotype / MGI
- impaired acrosome reaction / MGI
- behavior/neurological phenotype / MGI
- immune system phenotype / MGI
- teratozoospermia / MGI
- abnormal acrosome morphology / MGI
- abnormal sperm head morphology / MGI
- hairpin sperm flagellum / MGI
Literature references
- Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions.;Genoud Nicolas, Behrens Axel, Miele Gino, Robay Dimitri, Heppner Frank L, Freigang Stefan, Aguzzi Adriano, ;2004;Proceedings of the National Academy of Sciences of the United States of America;101;4198-203; 15007175