CAnN.129S7(B6)-Il1r1^tm1Imx/NickH

Status	Available to order
EMMA ID	EM:02496
International strain name	CAnN.129S7(B6)-Il1r1^tm1Imx/NickH
Alternative name	BALB/cAnNHsd Il1r1
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Il1r1^tm1Imx
Gene/Transgene symbol	Il1r1

Information from provider

Provider	Martin Nicklin
Provider affiliation	School of Medicine, University of Sheffield
Additional owner	Dr. Jacques Peschon, Institute of Systems Biology, Seattle WA, USA
Genetic information	N10 introgression of Il1r1^tm1Imx into BALB/cAnNHsd.
Phenotypic information	The mice are deficient in the only functional receptor for interleukin-1.
Breeding history	Received B6-Il1r1^tm1Imx from Immunex. Rederived to barrier and backcrossed 11 gen. to BALB/cAnN.
References	Phenotypic and functional characterization of mice that lack the type I receptor for IL-1.;Glaccum M B, Stocking K L, Charrier K, Smith J L, Willis C R, Maliszewski C, Livingston D J, Peschon J J, Morrissey P J, ;1997;Journal of immunology (Baltimore, Md. : 1950);159;3364-71; 9317135
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	not known

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archiving	homozygous BALB/cAnN
Breeding at archiving centre	Males were archived by sperm freezing on arrival. No breeding was performed at the archiving centre.

Disease and phenotype information

IMPC phenotypes (gene matching)

abnormal spleen morphology / IMPC
increased kidney weight / IMPC
enlarged heart / IMPC
enlarged kidney / IMPC
abnormal heart morphology / IMPC
abnormal kidney morphology / IMPC
enlarged spleen / IMPC

MGI phenotypes (allele matching)

increased body length / MGI
increased body weight / MGI
weight loss / MGI
decreased anxiety-related response / MGI
hypoactivity / MGI
increased circulating insulin level / MGI
abnormal nervous system electrophysiology / MGI
increased susceptibility to bacterial infection / MGI
enhanced wound healing / MGI
increased growth rate / MGI
increased liver weight / MGI
increased susceptibility to age related obesity / MGI
increased susceptibility to induced arthritis / MGI
abnormal lean body mass / MGI
increased circulating insulin-like growth factor I level / MGI
abnormal vascular wound healing / MGI
sepsis / MGI
impaired glucose tolerance / MGI
insulin resistance / MGI
abnormal food intake / MGI
increased percent body fat/body weight / MGI
increased circulating leptin level / MGI
increased body mass index / MGI
decreased tumor necrosis factor secretion / MGI
decreased circulating interleukin-6 level / MGI
increased circulating interleukin-18 level / MGI
decreased circulating interleukin-18 level / MGI
increased circulating interleukin-1 beta level / MGI
decreased interleukin-6 secretion / MGI
decreased transforming growth factor level / MGI
increased gonadal fat pad weight / MGI
increased abdominal fat pad weight / MGI
increased inguinal fat pad weight / MGI
increased mesenteric fat pad weight / MGI
increased retroperitoneal fat pad weight / MGI
enhanced contextual conditioning behavior / MGI
increased susceptibility to bacterial infection induced morbidity/mortality / MGI
increased total body fat amount / MGI
increased respiratory quotient / MGI
immune system phenotype / MGI
increased bone resorption / MGI
osteomyelitis / MGI
dental pulp necrosis / MGI
abnormal neutrophil physiology / MGI
abnormal response/metabolism to endogenous compounds / MGI
decreased susceptibility to kidney reperfusion injury / MGI
decreased susceptibility to experimental autoimmune uveoretinitis / MGI
decreased circulating creatinine level / MGI
decreased blood urea nitrogen level / MGI
delayed tooth eruption / MGI

MGI phenotypes (gene matching)

decreased neutrophil cell number / MGI
abnormal cell death / MGI
increased body length / MGI
increased body weight / MGI
weight loss / MGI
decreased anxiety-related response / MGI
hypoactivity / MGI
abnormal inflammatory response / MGI
increased circulating insulin level / MGI
no abnormal phenotype detected / MGI
abnormal nervous system electrophysiology / MGI
increased susceptibility to bacterial infection / MGI
decreased immunoglobulin level / MGI
abnormal neutrophil physiology / MGI
enhanced wound healing / MGI
increased growth rate / MGI
increased liver weight / MGI
delayed tooth eruption / MGI
increased susceptibility to age related obesity / MGI
decreased susceptibility to induced arthritis / MGI
abnormal response/metabolism to endogenous compounds / MGI
increased susceptibility to induced arthritis / MGI
impaired febrile response / MGI
abnormal lean body mass / MGI
decreased susceptibility to kidney reperfusion injury / MGI
decreased incidence of tumors by chemical induction / MGI
increased circulating insulin-like growth factor I level / MGI
decreased susceptibility to autoimmune diabetes / MGI
decreased susceptibility to experimental autoimmune uveoretinitis / MGI
abnormal vascular wound healing / MGI
increased bone resorption / MGI
decreased eosinophil cell number / MGI
decreased T cell number / MGI
sepsis / MGI
decreased T cell proliferation / MGI
osteomyelitis / MGI
impaired glucose tolerance / MGI
insulin resistance / MGI
homeostasis/metabolism phenotype / MGI
immune system phenotype / MGI
abnormal food intake / MGI
increased percent body fat/body weight / MGI
decreased circulating creatinine level / MGI
decreased blood urea nitrogen level / MGI
decreased susceptibility to type IV hypersensitivity reaction / MGI
increased circulating leptin level / MGI
increased body mass index / MGI
decreased tumor necrosis factor secretion / MGI
decreased circulating interleukin-6 level / MGI
increased circulating interleukin-18 level / MGI
decreased circulating interleukin-18 level / MGI
increased circulating interleukin-1 beta level / MGI
decreased interleukin-6 secretion / MGI
impaired neutrophil chemotaxis / MGI
decreased transforming growth factor level / MGI
increased gonadal fat pad weight / MGI
increased abdominal fat pad weight / MGI
increased inguinal fat pad weight / MGI
increased mesenteric fat pad weight / MGI
increased retroperitoneal fat pad weight / MGI
enhanced contextual conditioning behavior / MGI
increased susceptibility to bacterial infection induced morbidity/mortality / MGI
increased total body fat amount / MGI
abnormal circulating serum amyloid protein level / MGI
increased respiratory quotient / MGI
abnormal microglial cell activation / MGI
integument phenotype / MGI
dental pulp necrosis / MGI

Literature references

Phenotypic and functional characterization of mice that lack the type I receptor for IL-1.;Glaccum M B, Stocking K L, Charrier K, Smith J L, Willis C R, Maliszewski C, Livingston D J, Peschon J J, Morrissey P J, ;1997;Journal of immunology (Baltimore, Md. : 1950);159;3364-71; 9317135

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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CAnN.129S7(B6)-Il1r1tm1Imx/NickH