CAnN.129P2(MF1)-Il1rn^tm1Nick/NickH

Status	Available to order
EMMA ID	EM:02497
International strain name	CAnN.129P2(MF1)-Il1rn^tm1Nick/NickH
Alternative name	BALB/cAnNHsd Il1rn
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Il1rn^tm1Nick
Gene/Transgene symbol	Il1rn

Information from provider

Provider	Martin Nicklin
Provider affiliation	School of Medicine, University of Sheffield
Genetic information	Inactivation of all isoforms of Il1rn by targeted replacement. Mutant locus contains plasmid and Neo marker. Strain lacks interleukin-1 receptor antagonist.
Phenotypic information	Strain sporadically and independently develops rheumatoid-like arthritis, localised psoriasis-like lesions and patchy transmural destructive arteritis of the elastic vessels. Hygiene dependent (negative correlation). Different strain dependence of each disease. This strain, in our SPF lab: 80% affected (each disease independently) at 200 days.
Breeding history	129P2/OlaHsd chim. outbred to MF1, inbred 4 gen., barrier rederived, backcrossed to BALB/cAnN.
References	Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene.;Nicklin M J, Hughes D E, Barton J L, Ure J M, Duff G W, ;2000;The Journal of experimental medicine;191;303-12; 10637274 Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist.;Shepherd Joanna, Little Matthew C, Nicklin Martin J H, ;2004;The Journal of investigative dermatology;122;665-9; 15086551 Elastic-vessel arteritis in interleukin-1 receptor antagonist-deficient mice involves effector Th1 cells and requires interleukin-1 receptor.;Shepherd Joanna, Nicklin Martin J H, ;2005;Circulation;111;3135-40; 15939811 Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis.;Abdollahi-Roodsaz Shahla, Joosten Leo A B, Koenders Marije I, Devesa Isabel, Roelofs Mieke F, Radstake Timothy R D J, Heuvelmans-Jacobs Marleen, Akira Shizuo, Nicklin Martin J H, Ribeiro-Dias Fátima, van den Berg Wim B, ;2008;The Journal of clinical investigation;118;205-16; 18060042
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archiving	homozygous BALB/cAnN
Breeding at archiving centre	Males were archived by sperm freezing on arrival. No breeding was performed at the archiving centre.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Sterile multifocal osteomyelitis with periostitis and pustulosis / Orphanet_210115

MGI phenotypes (allele matching)

aortitis / MGI
immune system phenotype / MGI
hemorrhage / MGI
premature death / MGI
chronic inflammation / MGI
artery stenosis / MGI
skin inflammation / MGI
psoriasis / MGI
skin lesions / MGI
abnormal epidermal layer morphology / MGI
thick epidermis / MGI
epidermal desquamation / MGI
abnormal dermal layer morphology / MGI
thick dermal layer / MGI
parakeratosis / MGI
abnormal keratinocyte physiology / MGI
rheumatoid arthritis / MGI
pathological neovascularization / MGI

MGI phenotypes (gene matching)

psoriasis / MGI
skin lesions / MGI
abnormal epidermal layer morphology / MGI
thick epidermis / MGI
epidermal desquamation / MGI
abnormal dermal layer morphology / MGI
thick dermal layer / MGI
decreased body weight / MGI
postnatal growth retardation / MGI
abnormal body temperature homeostasis / MGI
hemorrhage / MGI
reduced fertility / MGI
premature death / MGI
decreased susceptibility to bacterial infection / MGI
abnormal CD4-positive, alpha beta T cell morphology / MGI
abnormal T-helper 1 cell morphology / MGI
abnormal T-helper 2 cell morphology / MGI
chronic inflammation / MGI
granulomatous inflammation / MGI
abnormal immune system organ morphology / MGI
parakeratosis / MGI
abnormal keratinocyte physiology / MGI
rheumatoid arthritis / MGI
pathological neovascularization / MGI
abnormal vascular wound healing / MGI
skin inflammation / MGI
increased acute inflammation / MGI
decreased circulating cholesterol level / MGI
immune system phenotype / MGI
artery stenosis / MGI
abnormal dendritic cell differentiation / MGI
abnormal dendritic cell number / MGI
decreased circulating interleukin-1 level / MGI
increased circulating interleukin-6 level / MGI
increased interleukin-17 secretion / MGI
increased susceptibility to endotoxin shock / MGI
aortitis / MGI
abnormal circulating serum amyloid protein level / MGI

Literature references

Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene.;Nicklin M J, Hughes D E, Barton J L, Ure J M, Duff G W, ;2000;The Journal of experimental medicine;191;303-12; 10637274
Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist.;Shepherd Joanna, Little Matthew C, Nicklin Martin J H, ;2004;The Journal of investigative dermatology;122;665-9; 15086551
Elastic-vessel arteritis in interleukin-1 receptor antagonist-deficient mice involves effector Th1 cells and requires interleukin-1 receptor.;Shepherd Joanna, Nicklin Martin J H, ;2005;Circulation;111;3135-40; 15939811
Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis.;Abdollahi-Roodsaz Shahla, Joosten Leo A B, Koenders Marije I, Devesa Isabel, Roelofs Mieke F, Radstake Timothy R D J, Heuvelmans-Jacobs Marleen, Akira Shizuo, Nicklin Martin J H, Ribeiro-Dias Fátima, van den Berg Wim B, ;2008;The Journal of clinical investigation;118;205-16; 18060042
[¹⁸F]FDG PET-MR characterization of aortitis in the IL1rn^-/- mouse model of giant-cell arteritis.;Deshayes Samuel, Baugé Caroline, Dupont Pierre-Antoine, Simard Christophe, Rida Hanan, de Boysson Hubert, Manrique Alain, Aouba Achille, ;2023;EJNMMI research;13;103; 38019303

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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CAnN.129P2(MF1)-Il1rntm1Nick/NickH