- abnormal skin morphology / IMPC
- increased large unstained cell number / IMPC
- increased grip strength / IMPC
- increased basophil cell number / IMPC
- increased neutrophil cell number / IMPC
- increased eosinophil cell number / IMPC
- increased NK cell number / IMPC
- abnormal cholesterol homeostasis / IMPC
- decreased circulating calcium level / IMPC
- increased lymphocyte cell number / IMPC
- increased effector memory CD8-positive, alpha-beta T cell number / IMPC
- increased circulating aspartate transaminase level / IMPC
- enlarged heart / IMPC
- increased leukocyte cell number / IMPC
- decreased monocyte cell number / IMPC
- abnormal heart morphology / IMPC
- decreased neutrophil cell number / IMPC
B6.129P2-Tnfrsf1atm1Blt/Cnrm
Status | Available to order |
EMMA ID | EM:02523 |
International strain name | B6.129P2-Tnfrsf1atm1Blt/Cnrm |
Alternative name | B6.129S/SvEv-Tnfrsf1a |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Tnfrsf1atm1Blt |
Gene/Transgene symbol | Tnfrsf1a |
Information from provider
Provider | Horst Bluethmann |
Provider affiliation | Pharmaceuticals Divisons, F. Hoffmann-La Roche Ltd. |
Genetic information | A genomic fragment containing exons II and III and 5' sequences from exon IV of the Tnfrsf1a gene was replaced by a neomycin resistance gene flanked by phosphoglycerate kinase-1 (pgk-1) promoter and poly (A)+ signal sequences. The insertion of the neo cassette resulted in the introduction of new BglII and StuI sites which were used to confirm the targeting event. The Tnfrsf1a homologies provided at both sides of the neo cassette were 868 bp and ~ 5 kb, respectively. The targeting vector was linearized with XbaI before electroporation into E14 embryonic stem cells derived from 129/Sv mice. |
Phenotypic information | Mice lacking the tumor necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. |
Breeding history | Backcrossed for 10 generations to C57BL/6, then intercrossed to generate a homozygous mutant line. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | yes |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Tumor necrosis factor receptor 1 associated periodic syndrome / Orphanet_32960
IMPC phenotypes (gene matching)
MGI phenotypes (allele matching)
- abnormal response/metabolism to endogenous compounds / MGI
- decreased circulating interleukin-6 level / MGI
- decreased sensitivity to induced morbidity/mortality / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
- abnormal sleep pattern / MGI
- impaired central nervous system regeneration / MGI
- increased sensitivity to induced cell death / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- impaired humoral immune response / MGI
- decreased susceptibility to bacterial infection / MGI
- decreased circulating alanine transaminase level / MGI
- abnormal Peyer's patch morphology / MGI
- abnormal immune system physiology / MGI
- abnormal lymph node B cell domain morphology / MGI
- abnormal Peyer's patch follicle morphology / MGI
- increased susceptibility to bacterial infection / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- increased susceptibility to parasitic infection / MGI
- increased susceptibility to type I hypersensitivity reaction / MGI
- decreased Peyer's patch number / MGI
- absent follicular dendritic cells / MGI
- decreased IgG1 level / MGI
- decreased interleukin-6 secretion / MGI
MGI phenotypes (gene matching)
- increased bone mineral density / MGI
- abnormal Peyer's patch morphology / MGI
- abnormal sleep pattern / MGI
- abnormal immune system physiology / MGI
- decreased IgG level / MGI
- liver inflammation / MGI
- lung inflammation / MGI
- decreased inflammatory response / MGI
- increased skin papilloma incidence / MGI
- decreased tumor incidence / MGI
- abnormal respiratory mechanics / MGI
- abnormal airway responsiveness / MGI
- abnormal lymph node B cell domain morphology / MGI
- abnormal spleen germinal center morphology / MGI
- abnormal Peyer's patch follicle morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal macrophage physiology / MGI
- granulomatous inflammation / MGI
- impaired skin barrier function / MGI
- abnormal glutamate-mediated receptor currents / MGI
- decreased circulating alanine transaminase level / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- abnormal nervous system physiology / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- increased susceptibility to parasitic infection / MGI
- increased susceptibility to type I hypersensitivity reaction / MGI
- decreased Peyer's patch number / MGI
- abnormal follicular dendritic cell morphology / MGI
- absent follicular dendritic cells / MGI
- decreased IgG1 level / MGI
- increased circulating tumor necrosis factor level / MGI
- decreased circulating interleukin-6 level / MGI
- decreased circulating interleukin-1 beta level / MGI
- increased interleukin-6 secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal chemokine secretion / MGI
- decreased susceptibility to endotoxin shock / MGI
- increased susceptibility to endotoxin shock / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- increased sensitivity to induced cell death / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- decreased sensitivity to induced morbidity/mortality / MGI
- decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI
- abnormal neuron proliferation / MGI
- abnormal oval cell physiology / MGI
- tumor regression / MGI
- impaired adaptive thermogenesis / MGI
- decreased susceptibility to dopaminergic neuron neurotoxicity / MGI
- decreased microglial cell number / MGI
- impaired humoral immune response / MGI
- impaired central nervous system regeneration / MGI
Literature references
- Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes.;Rothe J, Lesslauer W, Lötscher H, Lang Y, Koebel P, Köntgen F, Althage A, Zinkernagel R, Steinmetz M, Bluethmann H, ;1993;Nature;364;798-802; 8395024
Information on how we integrate external resources can be found here
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).