IMPC phenotypes (gene matching)
B6.129P2-B2mtm1Unc/Orl
| Status | Available to order |
| EMMA ID | EM:00029 |
| International strain name | B6.129P2-B2mtm1Unc/Orl |
| Alternative name | beta2m° |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | B2mtm1Unc |
| Gene/Transgene symbol | B2m |
Information from provider
| Provider | Beverly H. Koller |
| Provider affiliation | c/o CDTA-Orleans |
| Phenotypic information | The B2M protein is linked to MHC class I molecules. The mutant mice carry a null mutation in the beta-2 microglobulin (B2m) gene. Obtained by mutation of the B2m gene by homologous recombination (insertion of neomycin-resistance gene). Class I molecules are lacking or unstable on the cell surface, leading to a nearly elimination of the T CD8+ compartment. Cytotoxic immune responses are much altered. |
| Breeding history | 129P2/OlaHsd ES cells; 9 generations of backcross to C57BL/6, then intercross. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Immunodeficiency by defective expression of MHC class I / Orphanet_34592
- Variant ABeta2M amyloidosis / Orphanet_314652
MGI phenotypes (allele matching)
- decreased level of surface class I molecules / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased IgG level / MGI
- abnormal pancreas morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- increased IgM level / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased circulating serum albumin level / MGI
- increased T-helper 1 cell number / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- abnormal pancreatic beta cell morphology / MGI
- abnormal T cell number / MGI
- insulitis / MGI
MGI phenotypes (gene matching)
- absent CD8-positive, alpha-beta T cells / MGI
- decreased IgG level / MGI
- decreased level of surface class I molecules / MGI
- abnormal pancreas morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- abnormal CD8-positive, alpha-beta cytotoxic T cell morphology / MGI
- increased IgM level / MGI
- insulitis / MGI
- abnormal lateral geniculate nucleus morphology / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased susceptibility to parasitic infection / MGI
- abnormal cytotoxic T cell physiology / MGI
- abnormal pancreatic beta cell morphology / MGI
- decreased circulating serum albumin level / MGI
- hemochromatosis / MGI
- abnormal T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- increased T-helper 1 cell number / MGI
- increased gamma-delta T cell number / MGI
- increased gamma-delta intraepithelial T cell number / MGI
- increased tumor necrosis factor secretion / MGI
- increased interleukin-3 secretion / MGI
- decreased interleukin-4 secretion / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
Literature references
- Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells.;Koller B H, Marrack P, Kappler J W, Smithies O, ;1990;Science (New York, N.Y.);248;1227-30; 2112266