- thickened cerebral cortex / MGI
- increased brain weight / MGI
- abnormal T-helper 2 physiology / MGI
- decreased susceptibility to type I hypersensitivity reaction / MGI
- increased hippocampus volume / MGI
- nervous system phenotype / MGI
- decreased IgG level / MGI
- abnormal B cell morphology / MGI
- decreased susceptibility to parasitic infection / MGI
- decreased IgG1 level / MGI
- abnormal hippocampus morphology / MGI
- abnormal CNS glial cell morphology / MGI
- abnormal neuron morphology / MGI
- abnormal hippocampus CA1 region morphology / MGI
- abnormal hippocampus pyramidal cell morphology / MGI
- increased astrocyte number / MGI
- abnormal microglial cell morphology / MGI
- abnormal corpus callosum morphology / MGI
B6.129-Cd81tm1Lvy/Orl
Status | Available to order |
EMMA ID | EM:04305 |
International strain name | B6.129-Cd81tm1Lvy/Orl |
Alternative name | B6-backcrossed Cd81 knockout |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Cd81tm1Lvy |
Gene/Transgene symbol | Cd81 |
Information from provider
Provider | Shoshana Levy |
Provider affiliation | Department of Bioengineering, Stanford University |
Genetic information | Cd81 knockout mice. |
Phenotypic information | Female infertility, resistance to infection by Plasmodium sporozoites, impairment in the immune and nervous systems. |
Breeding history | Female infertility of Cd81 mice was manifested after the 4th backcross to a homozygous background (C57BL/6 and BALB/c). The mice have been backcrossed onto the C57BL/6 background for at least 8 generation. |
References |
|
Homozygous fertile | no |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | yes |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | homozygous C57BL/6J, wild-type C57BL/6J |
Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Common variable immunodeficiency / Orphanet_1572
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal microglial cell morphology / MGI
- abnormal immune system cell morphology / MGI
- abnormal corpus callosum morphology / MGI
- thickened cerebral cortex / MGI
- abnormal hippocampus morphology / MGI
- abnormal CNS glial cell morphology / MGI
- hypoactivity / MGI
- decreased IgG level / MGI
- increased dopamine level / MGI
- abnormal B cell differentiation / MGI
- increased brain weight / MGI
- abnormal macrophage physiology / MGI
- increased IgM level / MGI
- increased IgA level / MGI
- abnormal neuron morphology / MGI
- nervous system phenotype / MGI
- abnormal nucleus accumbens morphology / MGI
- abnormal B cell morphology / MGI
- decreased B-1 B cell number / MGI
- decreased susceptibility to parasitic infection / MGI
- decreased B cell proliferation / MGI
- abnormal T cell proliferation / MGI
- increased B cell proliferation / MGI
- abnormal T-helper 2 physiology / MGI
- decreased susceptibility to type I hypersensitivity reaction / MGI
- decreased B-1a cell number / MGI
- abnormal hippocampus CA1 region morphology / MGI
- decreased IgG1 level / MGI
- increased IgG3 level / MGI
- impaired behavioral response to cocaine / MGI
- abnormal hippocampus pyramidal cell morphology / MGI
- increased astrocyte number / MGI
- increased hippocampus volume / MGI
Literature references
- Normal lymphocyte development but delayed humoral immune response in CD81-null mice.;Maecker H T, Levy S, ;1997;The Journal of experimental medicine;185;1505-10; 9126932
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