B6.129S2(Cg)-Tbc1d10ctm1.2Psou/Orl

Status

Available to order

EMMA IDEM:06915
International strain nameB6.129S2(Cg)-Tbc1d10ctm1.2Psou/Orl
Alternative nameCarabin KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolTbc1d10ctm1.2Psou
Gene/Transgene symbolTbc1d10c

Information from provider

ProviderPauline Soulas-Sprauel
Provider affiliationCRBS (Centre de Recherche en Biomédecine), Inserm UMR 1109 (Immuno-Rhumatologie Moléculaire, IRM)
Genetic informationCarabin complete KO mice (see reference Schickel JN et coll, 2012, EMBO Mol Med, PMID: 23109291)
Phenotypic informationIncreased B cell response in vitro and in vivo. Development of autoantibodies and glomerulonephritis after CpGDNA (TLR9 agonist) injection, in vivo (see reference Schickel JN et coll, 2012, EMBO Mol Med, PMID: 23109291)
Breeding history12 backcrosses to C57BL/6 mice. Currently backcrossed to C57BL/6.
References
  • Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunity.;Schickel Jean-Nicolas, Pasquali Jean-Louis, Soley Anne, Knapp Anne-Marie, Decossas Marion, Kern Aurélie, Fauny Jean-Daniel, Marcellin Luc, Korganow Anne-Sophie, Martin Thierry, Soulas-Sprauel Pauline, ;2012;EMBO molecular medicine;4;1261-75; 23109291
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous C57BL/6J

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal T cell activation / MGI
  • abnormal B cell physiology / MGI
  • increased IgG level / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased susceptibility to systemic lupus erythematosus / MGI
  • abnormal response to infection / MGI
  • increased T cell proliferation / MGI
  • immune system phenotype / MGI
MGI phenotypes (gene matching)
  • abnormal T cell activation / MGI
  • abnormal B cell physiology / MGI
  • increased IgG level / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased susceptibility to systemic lupus erythematosus / MGI
  • abnormal response to infection / MGI
  • increased T cell proliferation / MGI
  • immune system phenotype / MGI

Literature references

  • Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunity.;Schickel Jean-Nicolas, Pasquali Jean-Louis, Soley Anne, Knapp Anne-Marie, Decossas Marion, Kern Aurélie, Fauny Jean-Daniel, Marcellin Luc, Korganow Anne-Sophie, Martin Thierry, Soulas-Sprauel Pauline, ;2012;EMBO molecular medicine;4;1261-75; 23109291

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).