STOCK Tg(H2-K1-Ifnb1)10Seif Ifnar1tm1Agt/Orl

Status

Available to order

EMMA IDEM:07149
International strain nameSTOCK Tg(H2-K1-Ifnb1)10Seif Ifnar1tm1Agt/Orl
Alternative nameIfnar1tm1Agt/Ifnar1tm1Agt Tg(H2-K1-Ifnb1)10Seif/Tg(H2- K1-Ifnb1)10Seif
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolIfnar1tm1Agt, Tg(H2-K1-Ifnb1)10Seif
Gene/Transgene symbolIfnar1, Tg(H2-K1-Ifnb1)10Seif

Information from provider

ProviderIsabelle Seif
Provider affiliationNeuropharmacologie, Faculte de pharmacie (Universite Paris-Sud)
Genetic informationRandom integration of a transgene for IFN beta expressed under the control of a H2-K1 promoter resulted in insertion of the transgene into exon 2 of Prps1l3 and a partial duplication of Prps1l3 and Slc25a21.
Phenotypic informationExcess type I interferon signaling in the seminiferous tubules of Tg10 mice leads to germ cell loss and sterility. Testicular integrity and normal fertility is maintained in Tg10 mice invalidated for the type I IFN receptor (Tg10-Ifnar1-/-).
Breeding historyInbred for 5 generations.
References
  • Excess type I interferon signaling in the mouse seminiferous tubules leads to germ cell loss and sterility.;Satie Anne-Pascale, Mazaud-Guittot Severine, Seif Isabelle, Mahé Dominique, He Zhiguo, Jouve Guilhem, Jégou Bernard, Dejucq-Rainsford Nathalie, ;2011;The Journal of biological chemistry;286;23280-95; 21515676
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes
Immunocompromisedyes

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous C3H/He, homozygous C3H/He
Breeding at archiving centreMales: transgenic for Tg(H2-K1-Ifnb1)10Seif and homozygous knock-out for Ifnar1-tm1Agt. Females: transgenic and homozygous knock-out.

Disease and phenotype information

IMPC phenotypes (gene matching)
  • improved glucose tolerance / IMPC
  • decreased circulating fructosamine level / IMPC
  • decreased monocyte cell number / IMPC
  • decreased KLRG1-positive NK cell number / IMPC
  • increased circulating creatinine level / IMPC
  • abnormal vibrissa morphology / IMPC
  • increased bone mineral content / IMPC
  • increased circulating amylase level / IMPC
MGI phenotypes (allele matching)
  • decreased bone mineral density / MGI
  • increased tumor growth/size / MGI
  • abnormal osteoclast morphology / MGI
  • abnormal response to infection / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interferon-alpha secretion / MGI
  • decreased interferon-beta secretion / MGI
  • decreased interleukin-6 secretion / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • abnormal inflammatory response / MGI
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal immunoglobulin level / MGI
  • abnormal cytokine secretion / MGI
  • corneal vascularization / MGI
  • increased susceptibility to viral infection induced morbidity/mortality / MGI
  • abnormal NK cell physiology / MGI
  • altered susceptibility to infection / MGI
  • immune system phenotype / MGI
  • abnormal CD8-positive, alpha-beta T cell physiology / MGI
  • abnormal interferon-gamma secretion / MGI
  • increased circulating interleukin-12 level / MGI
  • abnormal testis morphology / MGI
  • seminiferous tubule degeneration / MGI
  • reduced male fertility / MGI
  • male infertility / MGI
  • abnormal spermiogenesis / MGI
  • decreased litter size / MGI
  • abnormal seminiferous tubule morphology / MGI
  • oligozoospermia / MGI
  • abnormal male reproductive system physiology / MGI
  • decreased testis weight / MGI
  • reproductive system phenotype / MGI
  • abnormal male germ cell apoptosis / MGI
  • early reproductive senescence / MGI
MGI phenotypes (gene matching)
  • decreased bone mineral density / MGI
  • increased leukocyte cell number / MGI
  • altered susceptibility to infection / MGI
  • abnormal inflammatory response / MGI
  • increased incidence of induced tumors / MGI
  • abnormal dendritic cell physiology / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal macrophage physiology / MGI
  • abnormal immunoglobulin level / MGI
  • abnormal cytokine secretion / MGI
  • no phenotypic analysis / MGI
  • increased tumor growth/size / MGI
  • abnormal CD8-positive, alpha-beta T cell physiology / MGI
  • increased incidence of tumors by chemical induction / MGI
  • abnormal osteoclast morphology / MGI
  • abnormal response to infection / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • immune system phenotype / MGI
  • corneal vascularization / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • decreased NK cell number / MGI
  • abnormal interferon-gamma secretion / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interferon-alpha secretion / MGI
  • decreased interferon-beta secretion / MGI
  • increased circulating interleukin-12 level / MGI
  • decreased interleukin-6 secretion / MGI
  • increased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • increased susceptibility to viral infection induced morbidity/mortality / MGI
  • abnormal NK cell physiology / MGI
  • abnormal testis morphology / MGI
  • seminiferous tubule degeneration / MGI
  • reduced male fertility / MGI
  • male infertility / MGI
  • abnormal spermiogenesis / MGI
  • decreased litter size / MGI
  • abnormal seminiferous tubule morphology / MGI
  • oligozoospermia / MGI
  • abnormal male reproductive system physiology / MGI
  • decreased testis weight / MGI
  • reproductive system phenotype / MGI
  • abnormal male germ cell apoptosis / MGI
  • early reproductive senescence / MGI

Literature references

  • Excess type I interferon signaling in the mouse seminiferous tubules leads to germ cell loss and sterility.;Satie Anne-Pascale, Mazaud-Guittot Severine, Seif Isabelle, Mahé Dominique, He Zhiguo, Jouve Guilhem, Jégou Bernard, Dejucq-Rainsford Nathalie, ;2011;The Journal of biological chemistry;286;23280-95; 21515676

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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