B6.129P2-Cd34tm1Szk/Cnbc

Status

Available to order

EMMA IDEM:07223
International strain nameB6.129P2-Cd34tm1Szk/Cnbc
Alternative nameCD34
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCd34tm1Szk
Gene/Transgene symbolCd34

Information from provider

ProviderTak W Mak
Provider affiliationDivision of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute
Genetic informationDeletion of the transmembrane domain in Exon 7 of CD34.
Phenotypic informationCD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein.
Breeding historyPure C57BL/6, backcrossed 10 times.
References
  • CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein.;Suzuki A, Andrew D P, Gonzalo J A, Fukumoto M, Spellberg J, Hashiyama M, Takimoto H, Gerwin N, Webb I, Molineux G, Amakawa R, Tada Y, Wakeham A, Brown J, McNiece I, Ley K, Butcher E C, Suda T, Gutierrez-Ramos J C, Mak T W, ;1996;Blood;87;3550-62; 8611677
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivinghomozygous C57BL/6J

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased cell proliferation / MGI
  • abnormal hair follicle morphology / MGI
  • abnormal epidermal layer morphology / MGI
  • abnormal epidermis stratum basale morphology / MGI
  • increased skin papilloma incidence / MGI
  • decreased incidence of tumors by chemical induction / MGI
  • decreased eosinophil cell number / MGI
  • immune system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • integument phenotype / MGI
MGI phenotypes (gene matching)
  • decreased cell proliferation / MGI
  • abnormal hair follicle morphology / MGI
  • abnormal epidermal layer morphology / MGI
  • abnormal epidermis stratum basale morphology / MGI
  • increased skin papilloma incidence / MGI
  • abnormal definitive hematopoiesis / MGI
  • decreased incidence of tumors by chemical induction / MGI
  • decreased eosinophil cell number / MGI
  • immune system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • abnormal common myeloid progenitor cell morphology / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • decreased erythroid progenitor cell number / MGI
  • decreased splenocyte number / MGI
  • integument phenotype / MGI

Literature references

  • CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein.;Suzuki A, Andrew D P, Gonzalo J A, Fukumoto M, Spellberg J, Hashiyama M, Takimoto H, Gerwin N, Webb I, Molineux G, Amakawa R, Tada Y, Wakeham A, Brown J, McNiece I, Ley K, Butcher E C, Suda T, Gutierrez-Ramos J C, Mak T W, ;1996;Blood;87;3550-62; 8611677

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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