MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
B6.129P2-Card6tm1Aldu/Cnbc
| Status | Available to order |
| EMMA ID | EM:07239 |
| International strain name | B6.129P2-Card6tm1Aldu/Cnbc |
| Alternative name | CARD 6 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Card6tm1Aldu |
| Gene/Transgene symbol | Card6 |
Information from provider
| Provider | Tak W Mak |
| Provider affiliation | Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute |
| Genetic information | Card6 +/fl ES cells were generated by homologous recombination using a targeting vector in which exon 4 of the murine Card6 gene was flanked by loxP sites. |
| Phenotypic information | We generated Card6-deficient (CARD6 -/-) mice and carried out extensive analyses of signaling pathways mediating innate and adaptive immune responses, including the NOD pathways, but did not detect any abnormalities. Moreover, Card6 -/- mice were just as susceptible as wild-type mice to infection by Salmonella enterica serovar typhimurium, Listeria monocytogenes, Candida albicans, lymphocytic choriomeningitis virus, or mouse adenovirus type 1. Thus, although structural and in vitro analyses strongly suggest an important role for CARD6 in immune defense, the physiological function of CARD6 remains obscure. |
| Breeding history | Backcrossed 10 times to C57BL/6. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6J |
Disease and phenotype information
Literature references
- Generation and characterization of the Anp32e-deficient mouse.;Reilly Patrick T, Afzal Samia, Wakeham Andrew, Haight Jillian, You-Ten Annick, Zaugg Kathrin, Dembowy Joanna, Young Ashley, Mak Tak W, ;2010;PloS one;5;e13597; 21049064
- CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation.;Dufner Almut, Duncan Gordon S, Wakeham Andrew, Elford Alisha R, Hall Håkan T, Ohashi Pamela S, Mak Tak W, ;2008;Molecular and cellular biology;28;1541-52; 18160713