- decreased bone mineral density / MGI
- abnormal dendritic cell physiology / MGI
- increased susceptibility to bacterial infection / MGI
- hematopoietic system phenotype / MGI
- decreased cerebral infarction size / MGI
- decreased platelet aggregation / MGI
- decreased trabecular bone mass / MGI
- decreased compact bone mass / MGI
- decreased B cell number / MGI
- immune system phenotype / MGI
- absent germinal center B cells / MGI
- decreased neutrophil cell number / MGI
- abnormal humoral immune response / MGI
- decreased IgA level / MGI
- decreased immunoglobulin level / MGI
- decreased IgE level / MGI
- decreased susceptibility to type II hypersensitivity reaction / MGI
- absent spleen germinal center / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased IgG2b level / MGI
- decreased IgG3 level / MGI
- increased granulocyte number / MGI
- abnormal spleen morphology / MGI
- spleen hypoplasia / MGI
- decreased body size / MGI
- arrested B cell differentiation / MGI
- decreased IgM level / MGI
- thymus hypoplasia / MGI
- arrested T cell differentiation / MGI
- increased susceptibility to infection / MGI
- abnormal effector T cell morphology / MGI
- increased natural killer cell mediated cytotoxicity / MGI
- decreased double-positive T cell number / MGI
- increased macrophage cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- lymph node hypoplasia / MGI
- absent mature B cells / MGI
- abnormal T cell receptor V(D)J recombination / MGI
- abnormal immunoglobulin V(D)J recombination / MGI
- decreased thymocyte number / MGI
- lung inflammation / MGI
- abnormal macrophage physiology / MGI
- colitis / MGI
- abnormal T-helper 1 physiology / MGI
- abnormal response to transplant / MGI
- abnormal interferon secretion / MGI
- abnormal chemokine secretion / MGI
- decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
- abnormal intestinal mucosa morphology / MGI
- abnormal B cell morphology / MGI
- decreased susceptibility to parasitic infection / MGI
- decreased double-negative T cell number / MGI
- increased double-negative T cell number / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- abnormal stomach mucosa morphology / MGI
- abnormal intestinal epithelium morphology / MGI
- abnormal B cell number / MGI
- decreased pre-B cell number / MGI
- decreased mature B cell number / MGI
- increased immature B cell number / MGI
- decreased immature B cell number / MGI
- abnormal gamma-delta T cell differentiation / MGI
STOCK Rag2tm1Fwa Cd40tm1Kik Tg(TcraH-Y,TcrbH-Y)71Vbo/Orl
Status | Available to order |
EMMA ID | EM:07463 |
International strain name | STOCK Rag2tm1Fwa Cd40tm1Kik Tg(TcraH-Y,TcrbH-Y)71Vbo/Orl |
Alternative name | Rag2-/- CD40-/- HY+/+Tg |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Cd40tm1Kik, Tg(TcraH-Y, TcrbH-Y)71Vbo |
Gene/Transgene symbol | Cd40, Tg(TcraH-Y,TcrbH-Y)71Vbo, Rag2 |
Information from provider
Provider | Benedita Rocha |
Provider affiliation | INSERM U 1020, INSERM |
Additional owner | Frederick W. Alt, Hitoshi Kikutani, Harald von Boehmer |
Genetic information | Mutant mice bearing a transgenic alpha-beta TCR specific for the HY male antigen restricted to major histocompatibility complex (https://www.informatics.jax.org/allele/MGI:3044562), and deficient in the Cd40 gene and the Rag2 recombinase gene (TgRAG2) were used to obtain monoclonal populations of CD8+ T cells. |
Phenotypic information | Mice will have a single population of lymphocytes, those expressing the TCR transgene. |
Breeding history | Currently bred as homozygotes for the Rag2 and Cd40 knock-out mutations and the TCR transgene. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | yes |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Breeding at archiving centre | Males are homozygous knock-out for Rag2 and Cd40, transgenic for the Tg(TcraH-Y,TcrbH-Y)71Vbo (HY) transgene. Females are homozygous knock-out for Rag2 and Cd40, heterozygous or wild-type for the Tg(TcraH-Y,TcrbH-Y)71Vbo (HY) transgene. |
Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hyper-IgM syndrome type 3 / Orphanet_101090
- Severe combined immunodeficiency due to complete RAG1/2 deficiency / Orphanet_331206
- Omenn syndrome / Orphanet_39041
- Combined immunodeficiency with granulomatosis / Orphanet_157949
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- decreased neutrophil cell number / MGI
- abnormal humoral immune response / MGI
- decreased IgG level / MGI
- decreased IgM level / MGI
- decreased IgA level / MGI
- abnormal dendritic cell physiology / MGI
- increased susceptibility to bacterial infection / MGI
- decreased immunoglobulin level / MGI
- abnormal immunoglobulin level / MGI
- decreased IgE level / MGI
- increased IgM level / MGI
- decreased B cell number / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- decreased susceptibility to type II hypersensitivity reaction / MGI
- abnormal response to transplant / MGI
- decreased cerebral infarction size / MGI
- absent germinal center B cells / MGI
- absent spleen germinal center / MGI
- decreased spleen germinal center number / MGI
- decreased spleen germinal center size / MGI
- decreased IgG1 level / MGI
- decreased IgG2a level / MGI
- decreased IgG2b level / MGI
- decreased IgG3 level / MGI
- increased IgG3 level / MGI
- abnormal lymph node germinal center morphology / MGI
- decreased platelet aggregation / MGI
- decreased trabecular bone mass / MGI
- decreased compact bone mass / MGI
- impaired humoral immune response / MGI
- decreased monocyte cell number / MGI
- increased granulocyte number / MGI
- decreased bone marrow cell number / MGI
- alopecia / MGI
- abnormal digestive system morphology / MGI
- abnormal intestinal epithelium morphology / MGI
- abnormal intestinal mucosa morphology / MGI
- abnormal spleen morphology / MGI
- small spleen / MGI
- spleen hypoplasia / MGI
- abnormal Peyer's patch morphology / MGI
- abnormal thymus morphology / MGI
- decreased thymocyte number / MGI
- abnormal immune system cell morphology / MGI
- decreased body size / MGI
- abnormal humoral immune response / MGI
- arrested B cell differentiation / MGI
- decreased IgG level / MGI
- decreased IgM level / MGI
- decreased IgA level / MGI
- thymus hypoplasia / MGI
- arrested T cell differentiation / MGI
- lung inflammation / MGI
- neoplasm / MGI
- abnormal B cell differentiation / MGI
- no abnormal phenotype detected / MGI
- small lymph nodes / MGI
- abnormal lymph node morphology / MGI
- abnormal lymphopoiesis / MGI
- abnormal pre-B cell morphology / MGI
- increased susceptibility to infection / MGI
- abnormal double-negative T cell morphology / MGI
- abnormal double-positive T cell morphology / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal effector T cell morphology / MGI
- abnormal macrophage physiology / MGI
- abnormal B cell number / MGI
- abnormal B cell physiology / MGI
- abnormal immune system organ morphology / MGI
- colitis / MGI
- absent Peyer's patches / MGI
- increased natural killer cell mediated cytotoxicity / MGI
- erythroderma / MGI
- abnormal lymphocyte physiology / MGI
- abnormal B cell morphology / MGI
- decreased lymphocyte cell number / MGI
- decreased B cell number / MGI
- decreased T cell number / MGI
- decreased susceptibility to parasitic infection / MGI
- decreased double-negative T cell number / MGI
- increased double-negative T cell number / MGI
- decreased double-positive T cell number / MGI
- decreased T cell proliferation / MGI
- cachexia / MGI
- increased macrophage cell number / MGI
- abnormal T-helper 1 physiology / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- abnormal response to transplant / MGI
- abnormal T cell morphology / MGI
- decreased NK T cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- lymph node hypoplasia / MGI
- decreased pre-B cell number / MGI
- decreased mature B cell number / MGI
- absent mature B cells / MGI
- increased immature B cell number / MGI
- decreased immature B cell number / MGI
- abnormal gamma-delta T cell differentiation / MGI
- decreased spleen white pulp amount / MGI
- abnormal interferon secretion / MGI
- abnormal chemokine secretion / MGI
- abnormal T cell receptor V(D)J recombination / MGI
- abnormal immunoglobulin V(D)J recombination / MGI
- absent Hassall's corpuscle / MGI
- small inguinal lymph nodes / MGI
- decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
- increased DN3 thymocyte number / MGI
- abnormal stomach mucosa morphology / MGI
- small cervical lymph nodes / MGI
Literature references
- A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory.;Bourgeois Christine, Rocha Benedita, Tanchot Corinne, ;2002;Science (New York, N.Y.);297;2060-3; 12242444
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