IMPC phenotypes (gene matching)
B6.Cg-B2mtm1Unc Cd3etm1Mal H2-K1b-tm1Bpe H2-D1b-tm1Bpe/Orl
| Status | Available to order |
| EMMA ID | EM:00754 |
| International strain name | B6.Cg-B2mtm1Unc Cd3etm1Mal H2-K1b-tm1Bpe H2-D1b-tm1Bpe/Orl |
| Alternative name | TetraKO - CD3- and MHC class I- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cd3etm1Mal, B2mtm1Unc, H2-D1b-tm1Bpe, H2-K1b-tm1Bpe |
| Gene/Transgene symbol | Cd3e, B2m, H2-D1, H2-K1 |
Information from provider
| Provider | Antonio Freitas |
| Provider affiliation | Institut Pasteur |
| Genetic information | Inactivation of the Cd3epsilon gene. Inactivation of the b allele of both D and K loci of the MHC class I molecules. Inactivation of the beta2-microglobulin gene. |
| Phenotypic information | Lack of T lymphocytes and MHC class I molecules. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous 0, wild-type 0 |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Immunodeficiency by defective expression of MHC class I / Orphanet_34592
- Variant ABeta2M amyloidosis / Orphanet_314652
- T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta / Orphanet_169160
MGI phenotypes (allele matching)
- decreased level of surface class I molecules / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased IgG level / MGI
- abnormal pancreas morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- increased IgM level / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased circulating serum albumin level / MGI
- increased T-helper 1 cell number / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- abnormal pancreatic beta cell morphology / MGI
- abnormal T cell number / MGI
- insulitis / MGI
- arrested T cell differentiation / MGI
- abnormal double-negative T cell morphology / MGI
- abnormal B cell morphology / MGI
- abnormal regulatory T cell physiology / MGI
- absent T cells / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- absent CD4-positive, alpha beta T cells / MGI
MGI phenotypes (gene matching)
- absent CD8-positive, alpha-beta T cells / MGI
- decreased IgG level / MGI
- decreased level of surface class I molecules / MGI
- abnormal pancreas morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- abnormal CD8-positive, alpha-beta cytotoxic T cell morphology / MGI
- increased IgM level / MGI
- insulitis / MGI
- abnormal lateral geniculate nucleus morphology / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased susceptibility to parasitic infection / MGI
- abnormal cytotoxic T cell physiology / MGI
- abnormal pancreatic beta cell morphology / MGI
- decreased circulating serum albumin level / MGI
- hemochromatosis / MGI
- abnormal T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- increased T-helper 1 cell number / MGI
- increased gamma-delta T cell number / MGI
- increased gamma-delta intraepithelial T cell number / MGI
- increased tumor necrosis factor secretion / MGI
- increased interleukin-3 secretion / MGI
- decreased interleukin-4 secretion / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- abnormal thymus morphology / MGI
- small thymus / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- thymus hypoplasia / MGI
- arrested T cell differentiation / MGI
- seizures / MGI
- abnormal T cell differentiation / MGI
- abnormal double-negative T cell morphology / MGI
- abnormal double-positive T cell morphology / MGI
- absent CD4-positive, alpha beta T cells / MGI
- abnormal class switch recombination / MGI
- abnormal B cell morphology / MGI
- abnormal regulatory T cell physiology / MGI
- increased double-negative T cell number / MGI
- decreased double-positive T cell number / MGI
- abnormal T cell number / MGI
- increased T cell apoptosis / MGI
- abnormal T cell morphology / MGI
- absent T cells / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- increased DN3 thymocyte number / MGI
- demyelination / MGI
- abnormal immune system physiology / MGI
- abnormal T cell activation / MGI
- no phenotypic analysis / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- CNS inflammation / MGI
- abnormal immune system physiology / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI