B6.129-Prdm1tm3.1Liz/RobH
Status | Available to order |
EMMA ID | EM:08497 |
International strain name | B6.129-Prdm1tm3.1Liz/RobH |
Alternative name | Prdm1 tm5Rob |
Strain type | Targeted Mutant Strains : Other targeted |
Allele/Transgene symbol | Prdm1tm3.1Liz |
Gene/Transgene symbol | Prdm1 |
Information from provider
Provider | Elizabeth Robertson |
Provider affiliation | The Sir William Dunn School of Pathology, University of Oxford |
Genetic information | The Prdm1 delta-ex7 allele results in targeted deletion of exon 7 sequences and expression of only the short isoform of Prdm1. |
Phenotypic information | Homozygous:Prdm1 delta-ex7/delta-ex7 mice are embryonic lethal, and die at around E10.5 due to placental defects.Heterozygous:No observed phenotype in Prdm1 +/delta-ex7 mice. |
Breeding history | N. of generations backcrossed is >10 |
References |
|
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- double outlet right ventricle / MGI
- oligodactyly / MGI
- abnormal myotome development / MGI
- abnormal embryo development / MGI
- decreased embryo size / MGI
- abnormal placenta morphology / MGI
- abnormal placenta development / MGI
- decreased trophoblast giant cell number / MGI
- abnormal placenta labyrinth morphology / MGI
- hemorrhage / MGI
- no abnormal phenotype detected / MGI
- abnormal germ cell morphology / MGI
- abnormal aortic valve morphology / MGI
- abnormal pharyngeal arch morphology / MGI
- abnormal primordial germ cell migration / MGI
- no phenotypic analysis / MGI
- embryonic growth retardation / MGI
- right aortic arch / MGI
- abnormal dermomyotome development / MGI
- abnormal spongiotrophoblast layer morphology / MGI
- abnormal dorsal aorta morphology / MGI
- absent oocytes / MGI
- decreased testis weight / MGI
- uterine hemorrhage / MGI
- azoospermia / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- abnormal third pharyngeal arch morphology / MGI
- absent second pharyngeal arch / MGI
- absent plasma cells / MGI
- decreased primordial germ cell number / MGI
- absent primordial germ cells / MGI
- abnormal splenocyte physiology / MGI
- atrioventricular septal defect / MGI
- vascular ring / MGI
- abnormal left subclavian artery morphology / MGI
- absent third pharyngeal arch / MGI
- postnatal lethality, incomplete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- abnormal pharyngeal arch mesenchyme morphology / MGI
Literature references
- Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions.;Morgan Marc A J, Mould Arne W, Li Li, Robertson Elizabeth J, Bikoff Elizabeth K, ;2012;Molecular and cellular biology;32;3403-13; 22733990
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