B6.129-Prdm1tm3.1Liz/RobH

Status

Available to order

EMMA IDEM:08497
International strain nameB6.129-Prdm1tm3.1Liz/RobH
Alternative namePrdm1 tm5Rob
Strain typeTargeted Mutant Strains : Other targeted
Allele/Transgene symbolPrdm1tm3.1Liz
Gene/Transgene symbolPrdm1

Information from provider

ProviderElizabeth Robertson
Provider affiliationThe Sir William Dunn School of Pathology, University of Oxford
Genetic informationThe Prdm1 delta-ex7 allele results in targeted deletion of exon 7 sequences and expression of only the short isoform of Prdm1.
Phenotypic informationHomozygous:
Prdm1 delta-ex7/delta-ex7 mice are embryonic lethal, and die at around E10.5 due to placental defects.

Heterozygous:
No observed phenotype in Prdm1 +/delta-ex7 mice.
Breeding historyN. of generations backcrossed is >10
References
  • Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions.;Morgan Marc A J, Mould Arne W, Li Li, Robertson Elizabeth J, Bikoff Elizabeth K, ;2012;Molecular and cellular biology;32;3403-13; 22733990
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal embryo size / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • abnormal heart morphology / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
MGI phenotypes (allele matching)
  • abnormal embryo development / MGI
  • abnormal placenta morphology / MGI
  • embryonic growth retardation / MGI
  • immune system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
MGI phenotypes (gene matching)
  • double outlet right ventricle / MGI
  • oligodactyly / MGI
  • abnormal myotome development / MGI
  • abnormal embryo development / MGI
  • decreased embryo size / MGI
  • abnormal placenta morphology / MGI
  • abnormal placenta development / MGI
  • decreased trophoblast giant cell number / MGI
  • abnormal placenta labyrinth morphology / MGI
  • hemorrhage / MGI
  • no abnormal phenotype detected / MGI
  • abnormal germ cell morphology / MGI
  • abnormal aortic valve morphology / MGI
  • abnormal pharyngeal arch morphology / MGI
  • abnormal primordial germ cell migration / MGI
  • no phenotypic analysis / MGI
  • embryonic growth retardation / MGI
  • right aortic arch / MGI
  • abnormal dermomyotome development / MGI
  • abnormal spongiotrophoblast layer morphology / MGI
  • abnormal dorsal aorta morphology / MGI
  • absent oocytes / MGI
  • decreased testis weight / MGI
  • uterine hemorrhage / MGI
  • azoospermia / MGI
  • immune system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • abnormal third pharyngeal arch morphology / MGI
  • absent second pharyngeal arch / MGI
  • absent plasma cells / MGI
  • decreased primordial germ cell number / MGI
  • absent primordial germ cells / MGI
  • abnormal splenocyte physiology / MGI
  • atrioventricular septal defect / MGI
  • vascular ring / MGI
  • abnormal left subclavian artery morphology / MGI
  • absent third pharyngeal arch / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • abnormal pharyngeal arch mesenchyme morphology / MGI

Literature references

  • Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions.;Morgan Marc A J, Mould Arne W, Li Li, Robertson Elizabeth J, Bikoff Elizabeth K, ;2012;Molecular and cellular biology;32;3403-13; 22733990

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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