B6;129P2-Anxa6tm1Moss/H

Status

Available to order

EMMA IDEM:09630
International strain nameB6;129P2-Anxa6tm1Moss/H
Alternative nameB6;129-Anxa6tm1SM
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolAnxa6tm1Moss
Gene/Transgene symbolAnxa6

Information from provider

ProviderStephen Moss
Provider affiliationCell Biology, UCL Institute of Ophthalmology
Genetic informationInsertion of neo-pa gene into exon 3 of annexin A6 gene.
Phenotypic informationHomozygous:
Altered mechanical and intracellular calcium signalling in cardiomyocytes. Displays altered regulation of mitochondrial morphogenesis.

Heterozygous:
Not studied.
Breeding historyInbred since 1999.
References
  • Immunological development and cardiovascular function are normal in annexin VI null mutant mice.;Hawkins T E, Roes J, Rees D, Monkhouse J, Moss S E, ;1999;Molecular and cellular biology;19;8028-32; 10567528
  • Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null-mutant mice.;Song Guojie, Harding Sian E, Duchen Michael R, Tunwell Richard, O'Gara Peter, Hawkins Tim E, Moss Stephen E, ;2002;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;16;622-4; 11919174
  • Deficiency of annexins A5 and A6 induces complex changes in the transcriptome of growth plate cartilage but does not inhibit the induction of mineralization.;Belluoccio Daniele, Grskovic Ivan, Niehoff Anja, Schlötzer-Schrehardt Ursula, Rosenbaum Sabrina, Etich Julia, Frie Christian, Pausch Friedericke, Moss Stephen E, Pöschl Ernst, Bateman John F, Brachvogel Bent, ;2010;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;25;141-53; 19580468
  • Intracellular modulation of signaling pathways by annexin A6 regulates terminal differentiation of chondrocytes.;Minashima Takeshi, Small William, Moss Stephen E, Kirsch Thorsten, ;2012;The Journal of biological chemistry;287;14803-15; 22399299
  • Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle-mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response.;Grskovic Ivan, Kutsch Anna, Frie Christian, Groma Gergely, Stermann Jacek, Schlötzer-Schrehardt Ursula, Niehoff Anja, Moss Stephen E, Rosenbaum Sabrina, Pöschl Ernst, Chmielewski Markus, Rappl Gunter, Abken Hinrich, Bateman John F, Cheah Kathryn Se, Paulsson Mats, Brachvogel Bent, ;2012;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;27;2399-412; 22692895
  • Regulation of mitochondrial morphogenesis by annexin A6.;Chlystun Marcin, Campanella Michelangelo, Law Ah-Lai, Duchen Michael R, Fatimathas Lux, Levine Tim P, Gerke Volker, Moss Stephen E, ;2013;PloS one;8;e53774; 23341998
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased circulating LDL cholesterol level / IMPC
  • increased startle reflex / IMPC
  • abnormal eye size / IMPC
  • decreased circulating cholesterol level / IMPC
  • abnormal vibrissa morphology / IMPC
MGI phenotypes (allele matching)
  • cardiovascular system phenotype / MGI
  • immune system phenotype / MGI
  • increased ventricle muscle contractility / MGI
MGI phenotypes (gene matching)
  • abnormal vibrissa morphology / MGI
  • abnormal eye size / MGI
  • cardiovascular system phenotype / MGI
  • immune system phenotype / MGI
  • increased ventricle muscle contractility / MGI

Literature references

  • Immunological development and cardiovascular function are normal in annexin VI null mutant mice.;Hawkins T E, Roes J, Rees D, Monkhouse J, Moss S E, ;1999;Molecular and cellular biology;19;8028-32; 10567528
  • Altered mechanical properties and intracellular calcium signaling in cardiomyocytes from annexin 6 null-mutant mice.;Song Guojie, Harding Sian E, Duchen Michael R, Tunwell Richard, O'Gara Peter, Hawkins Tim E, Moss Stephen E, ;2002;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;16;622-4; 11919174
  • Deficiency of annexins A5 and A6 induces complex changes in the transcriptome of growth plate cartilage but does not inhibit the induction of mineralization.;Belluoccio Daniele, Grskovic Ivan, Niehoff Anja, Schlötzer-Schrehardt Ursula, Rosenbaum Sabrina, Etich Julia, Frie Christian, Pausch Friedericke, Moss Stephen E, Pöschl Ernst, Bateman John F, Brachvogel Bent, ;2010;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;25;141-53; 19580468
  • Intracellular modulation of signaling pathways by annexin A6 regulates terminal differentiation of chondrocytes.;Minashima Takeshi, Small William, Moss Stephen E, Kirsch Thorsten, ;2012;The Journal of biological chemistry;287;14803-15; 22399299
  • Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle-mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response.;Grskovic Ivan, Kutsch Anna, Frie Christian, Groma Gergely, Stermann Jacek, Schlötzer-Schrehardt Ursula, Niehoff Anja, Moss Stephen E, Rosenbaum Sabrina, Pöschl Ernst, Chmielewski Markus, Rappl Gunter, Abken Hinrich, Bateman John F, Cheah Kathryn Se, Paulsson Mats, Brachvogel Bent, ;2012;Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research;27;2399-412; 22692895
  • Regulation of mitochondrial morphogenesis by annexin A6.;Chlystun Marcin, Campanella Michelangelo, Law Ah-Lai, Duchen Michael R, Fatimathas Lux, Levine Tim P, Gerke Volker, Moss Stephen E, ;2013;PloS one;8;e53774; 23341998

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