B10.Cg-H2k2 Tg(TcrHEL3A9)1Mmd(?) Tg(IRBP-HEL)1Rc/H

Status

Available to order

EMMA IDEM:02251
Citation informationRRID:IMSR_EM:02251 

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International strain nameB10.Cg-H2k2 Tg(TcrHEL3A9)1Mmd(?) Tg(IRBP-HEL)1Rc/H
Alternative nameLo-Moe (TrpHEL3)
Strain typeTransgenic Strains
Allele/Transgene symbolTg(IRBP-HEL)1Rc, Tg(TcrHEL3A9)1Mmd, H2k2, H2-T18a
Gene/Transgene symbolTg(IRBP-HEL)1Rc, Tg(TcrHEL3A9)1Mmd, H2, H2-T18

Information from provider

ProviderRichard Cornall
Provider affiliationOxford University
Genetic informationRetina-specific membrane bound hen egg lysozyme, under the IRBP promoter. Some mice may also carry the anti-HEL 3A9 TCR transgene.
Phenotypic informationNone
References
  • Limited peripheral T cell anergy predisposes to retinal autoimmunity.;Lambe Teresa, Leung Janson C H, Ferry Helen, Bouriez-Jones Tiphaine, Makinen Kimmo, Crockford Tanya L, Jiang Hui R, Nickerson John M, Peltonen Leena, Forrester John V, Cornall Richard J, ;2007;Journal of immunology (Baltimore, Md. : 1950);178;4276-83; 17371984

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Breeding at archiving centreMales were archived by sperm freezing at the time of arrival. No breeding was performed at the archiving centre.

Disease and phenotype information

MGI phenotypes (gene matching)
  • decreased hematocrit / MGI
  • abnormal liver physiology / MGI
  • abnormal T cell differentiation / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal immunoglobulin level / MGI
  • increased IgM level / MGI
  • abnormal cytokine secretion / MGI
  • thyroid inflammation / MGI
  • increased autoantibody level / MGI
  • insulitis / MGI
  • increased susceptibility to autoimmune diabetes / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased susceptibility to parasitic infection / MGI
  • immune system phenotype / MGI
  • periinsulitis / MGI
  • abnormal T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • increased sensitivity to induced morbidity/mortality / MGI

Literature references

  • Limited peripheral T cell anergy predisposes to retinal autoimmunity.;Lambe Teresa, Leung Janson C H, Ferry Helen, Bouriez-Jones Tiphaine, Makinen Kimmo, Crockford Tanya L, Jiang Hui R, Nickerson John M, Peltonen Leena, Forrester John V, Cornall Richard J, ;2007;Journal of immunology (Baltimore, Md. : 1950);178;4276-83; 17371984

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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