B6.129-Gria2^tm3Rsp/Kctt

Status	Available to order
EMMA ID	EM:09212
International strain name	B6.129-Gria2^tm3Rsp/Kctt
Alternative name	Gria2tm3Rsp (Lab name B-2)
Strain type	Targeted Mutant Strains : Conditional mutation
Allele/Transgene symbol	Gria2^tm3Rsp,
Gene/Transgene symbol	Gria2

Information from provider

Provider	Rolf Sprengel
Provider affiliation	Molecular Neurobiology, Max-Planck-Institute for Medical Research
Genetic information	The GluA2fl floxed exon 11 allele allows deletion of the sequences encoding the glutamate receptor transmembrane domain ion channel pore in cells/tissues expressing Cre-recombinase.
Phenotypic information	Homozygous: No Phenotype Heterozygous: No Phenotype
Breeding history	Backcrosses since 2004
References	Forebrain-specific glutamate receptor B deletion impairs spatial memory but not hippocampal field long-term potentiation.;Shimshek Derya R, Jensen Vidar, Celikel Tansu, Geng Yu, Schupp Bettina, Bus Thorsten, Mack Volker, Marx Verena, Hvalby Øivind, Seeburg Peter H, Sprengel Rolf, ;2006;The Journal of neuroscience : the official journal of the Society for Neuroscience;26;8428-40; 16914668 Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons.;Shimshek Derya R, Bus Thorsten, Grinevich Valery, Single Frank N, Mack Volker, Sprengel Rolf, Spergel Daniel J, Seeburg Peter H, ;2006;Molecular endocrinology (Baltimore, Md.);20;219-31; 16099814 The AMPA receptor subunit GluR-B in its Q/R site-unedited form is not essential for brain development and function.;Kask K, Zamanillo D, Rozov A, Burnashev N, Sprengel R, Seeburg P H, ;1998;Proceedings of the National Academy of Sciences of the United States of America;95;13777-82; 9811877
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Karolinska Institutet, Stockholm, Sweden
Animals used for archiving	heterozygous 0

Literature references

Forebrain-specific glutamate receptor B deletion impairs spatial memory but not hippocampal field long-term potentiation.;Shimshek Derya R, Jensen Vidar, Celikel Tansu, Geng Yu, Schupp Bettina, Bus Thorsten, Mack Volker, Marx Verena, Hvalby Øivind, Seeburg Peter H, Sprengel Rolf, ;2006;The Journal of neuroscience : the official journal of the Society for Neuroscience;26;8428-40; 16914668
Impaired reproductive behavior by lack of GluR-B containing AMPA receptors but not of NMDA receptors in hypothalamic and septal neurons.;Shimshek Derya R, Bus Thorsten, Grinevich Valery, Single Frank N, Mack Volker, Sprengel Rolf, Spergel Daniel J, Seeburg Peter H, ;2006;Molecular endocrinology (Baltimore, Md.);20;219-31; 16099814
The AMPA receptor subunit GluR-B in its Q/R site-unedited form is not essential for brain development and function.;Kask K, Zamanillo D, Rozov A, Burnashev N, Sprengel R, Seeburg P H, ;1998;Proceedings of the National Academy of Sciences of the United States of America;95;13777-82; 9811877

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.

B6.129-Gria2tm3Rsp/Kctt