MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
B6N.129-Gria3tm1Rsp/Kctt
| Status | Available to order |
| EMMA ID | EM:09215 |
| International strain name | B6N.129-Gria3tm1Rsp/Kctt |
| Alternative name | Gria3tm2Rsp (Lab name RC2) |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Gria3tm1Rsp, |
| Gene/Transgene symbol | Gria3 |
Information from provider
| Provider | Rolf Sprengel |
| Provider affiliation | Molecular Neurobiology, Max Planck Institute for Medical Research |
| Genetic information | The Gria3fl floxed exon 11 allele allows deletion of the sequences encoding the glutamate receptor transmembrane domain ion channel pore in cells/tissues expressing Cre-recombinase. These mice are useful in applications related to the study of behavioral, social and cognitive abnormalities. |
| Phenotypic information | Homozygous:No PhenotypeHeterozygous:No Phenotype |
| Breeding history | Generated in 2000. Embryos frozen 2002 |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | heterozygous C57BL/6N |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- X-linked intellectual disability due to GRIA3 mutations / Orphanet_364028
Literature references
- Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach.;Lu Wei, Shi Yun, Jackson Alexander C, Bjorgan Kirsten, During Matthew J, Sprengel Rolf, Seeburg Peter H, Nicoll Roger A, ;2009;Neuron;62;254-68; 19409270