Institutions and facilities

The Germ-Free Oeiras Service (GFOS), providing the EMMA axenic service

The GFOS is part of the core animal facility of the Instituto Gulbenkian de Ciência in Oeiras, Portugal. The IGC mouse facility is partitioned into 5 independent areas, each with a specific bio-containment level, including germ-free and strict SPF. The facility hosts about 50,000 mice that cover close to a 100 different inbred strains, available to in-house and associated research groups and visiting scientists. Production and experimental areas are designed to serve active research in various fields of biology (development, neurobiology, infectious diseases, immunology, genetics). Ongoing scientific projects at the IGC involving the GFOS are related to studies of immuno-compromised mice.


The GFOS is adapted for breeding and experimentation purposes. Rigid and flexible Isolators, transfer chambers and containers are equipped with the Double Door Rapid Transfer Port (DPTE®), a user-friendly and safe connecting system for introducing and removing equipment and other materials to and from sterile isolators. Like other research facilities at the IGC, the GFOS is available to scientists worldwide upon agreement from the Institute's Director. Moreover, scientists who want to work with these mice can be temporarily hosted at the Institute's laboratories if they wish to conduct their own experiments.


 Axenic service  Axenic service 2  axenic service 3


Other academic and non-profit institutions where gnotobiology research is conducted in Europe

Transgenesis, Archiving and Animal Models (TAAM), CNRS, Orléans, France

National Institute for Agronomic Research (INRA), MICALIS, Jouy-en-Josas Cedex, France

Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany

Core Facility for Germ Free Research (CFGR), Karolinska Institutet, Stockholm, Sweden

Instituto Gulbenkian de Ciência (IGC), Oeiras, Portugal

MRC Harwell, Harwell, UK


Additional institutions and other useful links are listed by the Association for Gnotobiotics.


For general enquiries on EMMA germ-free service
Dr. Michael Hagn
The European Mouse Mutant Archive
Helmholtz Zentrum München
Institute of Experimental Genetics
Ingolstädter Landstraße 1
85764 Neuherberg Germany
Phone: +49 89 31873628
FAX: +49 89 31873500


For scientific enquiries
EMMA Portugal
Instituto Gulbenkian de Ciência
Rua da Quinta Grande 6, Apartado 14
2781-901 Oeiras, Portugal
Phone: +351 21 440 79 08
FAX : + 351 21 440 79 70