- increased heart weight / IMPC
- preweaning lethality, complete penetrance / IMPC
- embryonic lethality prior to tooth bud stage / IMPC
- decreased circulating glucose level / IMPC
- increased grip strength / IMPC
- improved glucose tolerance / IMPC
- increased fasting circulating glucose level / IMPC
- increased circulating glucose level / IMPC
- embryonic lethality prior to organogenesis / IMPC
STOCK Cdc20tm1.1Mama/Cnbc
Status | Available to order |
EMMA ID | EM:06117 |
Citation information | RRID:IMSR_EM:06117 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | STOCK Cdc20tm1.1Mama/Cnbc |
Alternative name | Cdc20 |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Cdc20tm1.1Mama |
Gene/Transgene symbol | Cdc20 |
Information from provider
Provider | Marcos Malumbres |
Provider affiliation | Molecular Oncology, Centro Nacional de Investigaciones Oncologicas (CNIO) |
Genetic information | A loxP site was inserted upstream of exon 2, and an FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 2; flp-mediated recombination removed the neo cassette leaving exon 2 floxed. |
Phenotypic information | Before cre-mediated recombination there is no phenotype associated to this allele. |
Breeding history | Chimeras were crossed with C57BL/6J females for germ line transmission testing. To remove the neoR selection marker Aurkb+/loxfrt mice were crossed with Tg(ACTFLPe)9205Dym mice to remove the frt-flanked neomycin resistance cassette used for homologous recombination selection. Currently maintained by crossing homozygous mice. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Animals used for archiving | heterozygous males |
Disease and phenotype information
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- abnormal cell death / MGI
- decreased cell proliferation / MGI
- abnormal oocyte morphology / MGI
- decreased embryo size / MGI
- reduced female fertility / MGI
- female infertility / MGI
- increased tumor incidence / MGI
- no phenotypic analysis / MGI
- failure of zygotic cell division / MGI
- abnormal chromosome morphology / MGI
- maternal effect / MGI
- aneuploidy / MGI
- abnormal mitosis / MGI
- abnormal female meiosis / MGI
- reproductive system phenotype / MGI
- abnormal male germ cell morphology / MGI
- increased hepatoma incidence / MGI
- embryonic lethality before implantation, complete penetrance / MGI
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- embryonic lethality before implantation, incomplete penetrance / MGI
- increased lymphoma incidence / MGI
- increased embryonic tissue cell apoptosis / MGI
Literature references
- Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase.;Manchado Eusebio, Guillamot María, de Cárcer Guillermo, Eguren Manuel, Trickey Michelle, García-Higuera Irene, Moreno Sergio, Yamano Hiroyuki, Cañamero Marta, Malumbres Marcos, ;2010;Cancer cell;18;641-54; 21156286
Information on how we integrate external resources can be found here
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